The insulin factory: a tour of the plant surroundings and a visit to the assembly line. The Minkowski lecture 1973 revisited.
about
Proteolytic processing of chromogranin A in purified insulin granules. Formation of a 20 kDa N-terminal fragment (betagranin) by the concerted action of a Ca2+-dependent endopeptidase and carboxypeptidase H (EC 3.4.17.10)-Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Is Expressed in Pancreatic Cells and Functions in Insulin but Not -Aminobutyric Acid SecretionExpedited approaches to whole cell electron tomography and organelle mark-up in situ in high-pressure frozen pancreatic isletsPancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.Monitoring of exocytosis and endocytosis of insulin secretory granules in the pancreatic beta-cell line MIN6 using pH-sensitive green fluorescent protein (pHluorin) and confocal laser microscopyImaging a target of Ca2+ signalling: dense core granule exocytosis viewed by total internal reflection fluorescence microscopy.A transgene coding for a human insulin analog has a mitogenic effect on murine embryonic beta cellsMutant proinsulin that cannot be converted is secreted efficiently from primary rat beta-cells via the regulated pathway.Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases.Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes.Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling.Translational control of glucose-induced islet amyloid polypeptide production in pancreatic isletsIslet autoantigens: structure, function, localization, and regulation.Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.SNAP-25 is expressed in islets of Langerhans and is involved in insulin release.Pancreatic Transdifferentiation and Glucose-Regulated Production of Human Insulin in the H4IIE Rat Liver Cell Line.Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.Insulin granule biogenesis, trafficking and exocytosis.Mechanisms of insulin secretion in malnutrition: modulation by amino acids in rodent models.The gap junction: a channel for multiple functions?50 years forward: beta cells.Pancreatic Beta Cell Identity in Humans and the Role of Type 2 Diabetes.The morphology of proinsulin processing.Function of a genetically modified human liver cell line that stores, processes and secretes insulin.Sorting and processing of secretory proteins.A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moietiesIndividual beta cells within the intact islet differentially respond to glucose.Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells.Sequence requirements for proinsulin processing at the B-chain/C-peptide junction.Vectorial insulin secretion by pancreatic beta-cells.Differential rates of conversion of rat proinsulins I and II. Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin IIThe inhibition of proinsulin-processing endopeptidase activities by active-site-directed peptidesThe intracellular handling of insulin-related peptides in isolated pancreatic islets. Evidence for differential rates of degradation of insulin and C-peptide.Selective stimulation of glucagon secretion by beta 2-adrenoceptors in isolated islets of Langerhans of the rat.Expression of the protein tyrosine phosphatase-like protein IA-2 during pancreatic islet development.Differential kinetics of rat insulin I and II processing in rat islets of Langerhans.Sorting Ourselves Out: Seeking Consensus on Trafficking in the Beta-CellUltrastructural morphometric analysis of insulin secretory granules in human type 2 diabetesDes-(27-31)C-Peptide
P2860
Q28359771-A8EF008C-7A99-4F35-8041-44B82625C1E5Q29542190-907AC2E8-9C72-4F11-A2FD-C387CB59CA2EQ30482063-C5AE0AAD-4311-4EE6-A0CD-538CC9BDF197Q30708894-389BEB6E-C6C8-4320-9EC1-E416A9384883Q31043443-71EEC992-3D33-4B6B-90FA-6EFE8AE06B9CQ33375889-4610A9C7-504F-4179-9FAE-66057EDAA43FQ34109393-886DDEDF-674C-43D8-AC3F-C1C186484C02Q34814126-C7C65BAA-3C9C-493C-B5AA-1B5FAA42467FQ34967079-D5FD5562-DAD1-4161-B6F0-B8D748CCD79DQ35552583-7229817B-0432-4CC3-B297-C450211BC2B4Q35799671-A9DDE306-17EB-46BD-8753-7085C9916C6CQ35809926-1ED55EE4-8863-4046-8044-2A2E2C927132Q35920741-05A9B6E7-E51E-4A9F-8D07-207E758D49C7Q36119378-C30DA386-7E20-42A9-9218-513942158990Q36217982-29AC9960-8955-476E-9284-06B1207B3919Q36235424-5D91A87A-0C22-415B-BB74-378C645A9AF4Q36847139-DE037F39-ABB8-4181-8CCA-7FD0E9609DD0Q37378805-120A9777-60E8-4F8F-A60B-A1D00F830E04Q37403987-0637802C-83AC-4DA1-B14C-D579FC746700Q37780136-CDD412FC-85E5-4CE4-84D8-D97E9F846348Q38198550-01880F86-7D30-4FE4-A559-849B980D8D12Q39009169-1372E9C2-AF85-4814-950A-C1ECBB2535C2Q39355916-9A94F5DB-A1EA-4B7C-B096-A6E06CF7E838Q39767141-D2A20432-9704-47C3-80F5-26B811835762Q40665959-AA380BA1-AC57-450B-885F-EB097ACA9A9BQ40744676-83AA0485-958F-4211-9350-13D28BA0BFEBQ41035647-2045963D-4F77-456C-85BF-F9BF0A0B7452Q41087030-B2A2D0EA-A7E1-4CCA-B173-464CF708AA1DQ41256266-A00D613E-4BE6-4681-9588-4A7A2AB6F8F6Q41295257-9BF685EA-1D2C-4B8D-A60B-C56B213EF3E8Q41718260-83AA71D1-C988-4EB0-A1B2-8358444F4FB8Q41843202-288756BC-985F-441D-821F-9B5742B0CE7AQ42025341-F3C3D103-BBD5-4CDE-AE9C-3AD8A7E86FB7Q42062108-6B242D19-B824-4110-889A-E696A469ED64Q42716188-AB4EF9DD-C492-4DED-8703-8CFBF920A0B3Q43617511-79CD7656-E056-4542-A649-59097D342002Q46182479-8BBD7127-EB13-4271-B369-D592F5379856Q57374295-E02FC017-900E-4B17-AA0E-6D9B400B9599Q57503376-F8BE4A31-E331-411D-BBB4-9807958B890DQ58037274-7DB920B5-41C9-4817-9F14-E0A54081CFE9
P2860
The insulin factory: a tour of the plant surroundings and a visit to the assembly line. The Minkowski lecture 1973 revisited.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
1985年论文
@zh
1985年论文
@zh-cn
name
The insulin factory: a tour of ...... kowski lecture 1973 revisited.
@en
type
label
The insulin factory: a tour of ...... kowski lecture 1973 revisited.
@en
prefLabel
The insulin factory: a tour of ...... kowski lecture 1973 revisited.
@en
P2860
P356
P1433
P1476
The insulin factory: a tour of ...... kowski lecture 1973 revisited.
@en
P2093
P2860
P2888
P304
P356
10.1007/BF00281987
P577
1985-08-01T00:00:00Z
P6179
1000455678