The role of somatic hypermutation in the generation of antibody diversity.
about
In vitro evolution of single-chain antibodies using mRNA displayHigh-level secretion of recombinant monomeric murine and human single-chain Fv antibodies from Drosophila S2 cellsStructural Basis of HCV Neutralization by Human Monoclonal Antibodies Resistant to Viral Neutralization EscapeGeneration and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigenImmunoglobulin heavy chain gene expression in peripheral blood B lymphocytes.Antibody binding loop insertions as diversity elementsOxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseasesProtein evolution on partially correlated landscapes.Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen.Analysis of human antitopoisomerase-I idiotypesModeling and optimization of populations subject to time-dependent mutation.Multiple vaccine-elicited nonneutralizing antienvelope antibody activities contribute to protective efficacy by reducing both acute and chronic viremia following simian/human immunodeficiency virus SHIV89.6P challenge in rhesus macaques.Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell lineMolecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseasesMolecular pathology of primary intraocular lymphoma.Small molecule mimetics of an HIV-1 gp41 fusion intermediate as vaccine leads.Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand breakA well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene.Early preservation of CXCR5+ PD-1+ helper T cells and B cell activation predict the breadth of neutralizing antibody responses in chronic HIV-1 infection.Early high-affinity neutralizing anti-viral IgG responses without further overall improvements of affinity.DNA sequences at immunoglobulin switch region recombination sitesMolecular characterization of the cervical and systemic B-cell repertoire: Unique, yet overlapping, immune compartments of an HIV-1 resistant individual.Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergenceMolecular biomarkers for the diagnosis of primary vitreoretinal lymphomaSomatic mutation of human immunoglobulin V genes in the X-linked HyperIgM syndrome.The LRF transcription factor regulates mature B cell development and the germinal center response in miceImmunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of V kappa and V lambda segments and VJ combinations.Establishment of a novel B cell clonality analysis using single-strand conformation polymorphism of immunoglobulin light chain messenger signalsComprehensive mapping of functional epitopes on dengue virus glycoprotein E DIII for binding to broadly neutralizing antibodies 4E11 and 4E5A by phage display.Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell linesPOK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and functionPreferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytesThe mouse antibody response to infection with Cryptococcus neoformans: VH and VL usage in polysaccharide binding antibodies.Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven responseAnalysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.Exploring Human Antimicrobial Antibody Responses on a Single B Cell Level.Comparison of the specificity of antibodies to VAR2CSA in Cameroonian multigravidae with and without placental malaria: a retrospective case-control study.Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutationAnalysis of somatic mutations in kappa transgenes.Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.
P2860
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P2860
The role of somatic hypermutation in the generation of antibody diversity.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
The role of somatic hypermutation in the generation of antibody diversity.
@en
type
label
The role of somatic hypermutation in the generation of antibody diversity.
@en
prefLabel
The role of somatic hypermutation in the generation of antibody diversity.
@en
P2093
P356
P1433
P1476
The role of somatic hypermutation in the generation of antibody diversity.
@en
P2093
P304
P356
10.1126/SCIENCE.2658060
P407
P577
1989-06-01T00:00:00Z