Conformational and functional characterization of trapped complexes of the P-glycoprotein multidrug transporter.
about
Catalytic and transport cycles of ABC exporters.Characterization of an asymmetric occluded state of P-glycoprotein with two bound nucleotides: implications for catalysisAn asymmetric post-hydrolysis state of the ABC transporter ATPase dimer.Molecular-dynamics simulations of the ATP/apo state of a multidrug ATP-binding cassette transporter provide a structural and mechanistic basis for the asymmetric occluded stateKinetic validation of the models for P-glycoprotein ATP hydrolysis and vanadate-induced trapping. Proposal for additional steps.Conformational analysis of human ATP-binding cassette transporter ABCB1 in lipid nanodiscs and inhibition by the antibodies MRK16 and UIC2.Dynamic ligand-induced conformational rearrangements in P-glycoprotein as probed by fluorescence resonance energy transfer spectroscopy.Unravelling the complex drug-drug interactions of the cardiovascular drugs, verapamil and digoxin, with P-glycoprotein.The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis.Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbAThe reconstituted Escherichia coli MsbA protein displays lipid flippase activityA mutation within the extended X loop abolished substrate-induced ATPase activity of the human liver ATP-binding cassette (ABC) transporter MDR3Cooperativity between verapamil and ATP bound to the efflux transporter P-glycoprotein.Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates.Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1).
P2860
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P2860
Conformational and functional characterization of trapped complexes of the P-glycoprotein multidrug transporter.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Conformational and functional ...... protein multidrug transporter.
@en
type
label
Conformational and functional ...... protein multidrug transporter.
@en
prefLabel
Conformational and functional ...... protein multidrug transporter.
@en
P2860
P356
P1433
P1476
Conformational and functional ...... oprotein multidrug transporter
@en
P2093
Paula L Russell
P2860
P304
P356
10.1042/BJ20060015
P407
P577
2006-10-01T00:00:00Z