about
Receptor for advanced glycation end products and its involvement in inflammatory diseasesInsights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's diseaseStructure of amyloid A4-(1-40)-peptide of Alzheimer's diseaseIdentification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3.Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome.Theoretical models of the ion channel structure of amyloid beta-protein.The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter.Amyloid beta/A4 precursor protein (APP) processing in lysosomes.Purification and cloning of brain proteases capable of degrading the beta-amyloid precursor protein.Secretion of the beta-amyloid precursor protein.Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders.Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex.Pathogenic factors in vascular dementia and Alzheimer's disease. Multiple actions of heparin that probably are beneficial.Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowthMedicine in the elderly.Molecular cloning of human cDNA with a sequence highly similar to that of the dihydrofolate reductase gene in brain libraries derived from Alzheimer's disease patients.Amyloid-beta aggregation.Mechanisms of amyloid deposition in Alzheimer's disease.Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptideBeta-amyloid precursor protein cleavage by a membrane-bound protease.Amyloid precursor protein in aged nonhuman primates.Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease.Crosstalk between calcium, amyloid beta and the receptor for advanced glycation endproducts in Alzheimer's disease.Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.Membrane bilayer instability as a pathogenetic mechanism for neurological disease.Expression of L-APP mRNA in brain cells.Regulatory region of human amyloid precursor protein (APP) gene promotes neuron-specific gene expression in the CNS of transgenic mice.Extracellular matrix influences the biogenesis of amyloid precursor protein in microglial cells.Transforming growth factor beta mediates increase of mature transmembrane amyloid precursor protein in microglial cells.Aberrant proteolysis of the beta-amyloid precursor protein in familial Alzheimer's disease lymphoblastoid cells.The conformation of Alzheimer's beta peptide determines the rate of amyloid formation and its resistance to proteolysis.The S100B/RAGE Axis in Alzheimer's Disease.Internal repeats of prion protein and A beta PP, and reciprocal similarity with the amyloid-related proteins.Alzheimer's disease and the beta amyloid gene.Oligomerization of beta-amyloid of the Alzheimer's and the Dutch-cerebral-haemorrhage types.In-vitro matured human macrophages express Alzheimer's beta A4-amyloid precursor protein indicating synthesis in microglial cells.The alpha-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formation.beta-Amyloid (25-35) or substance P stimulates [3H]MK-801 binding to rat cortical membranes in the presence of glutamate and glycine.Human and rodent sequence analogs of Alzheimer's amyloid beta A4 share similar properties and can be solubilized in buffers of pH 7.4.
P2860
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P2860
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Molecular biology of Alzheimer's disease.
@en
type
label
Molecular biology of Alzheimer's disease.
@en
prefLabel
Molecular biology of Alzheimer's disease.
@en
P1476
Molecular biology of Alzheimer's disease.
@en
P2093
Beyreuther K
Müller-Hill B
P304
P356
10.1146/ANNUREV.BI.58.070189.001443
P577
1989-01-01T00:00:00Z