Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series.
about
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2Selective targeting of the stress chaperome as a therapeutic strategyProtein chaperones: a composition of matter review (2008 - 2013).Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directionsStructure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94The Chemical Biology of Molecular Chaperones--Implications for Modulation of ProteostasisCombinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease.The Hybrid Pyrroloisoindolone-Dehydropyrrolizine Alkaloid (-)-Chlorizidine A Targets Proteins within the Glycolytic Pathway.Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide ScaffoldNatural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside?A phase I trial of ganetespib in combination with paclitaxel and trastuzumab in patients with human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancerIdentification and characterization of the antiplasmodial activity of Hsp90 inhibitors.Development of radamide analogs as Grp94 inhibitorsResorcinol-Based Grp94-Selective Inhibitors.Proteomic interrogation of HSP90 and insights for medical research.Second Generation Grp94-Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer.8u, a pro-apoptosis/cell cycle arrest compound, suppresses invasion and metastasis through HSP90α downregulating and PI3K/Akt inactivation in hepatocellular carcinoma cells.Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.Adapting to stress - chaperome networks in cancer.Rapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-acyl-N-alkyl sulfonamide.
P2860
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P2860
Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Experimental and structural te ...... n the Hsp90 inhibitors series.
@en
type
label
Experimental and structural te ...... n the Hsp90 inhibitors series.
@en
prefLabel
Experimental and structural te ...... n the Hsp90 inhibitors series.
@en
P2093
P2860
P356
P1476
Experimental and structural te ...... n the Hsp90 inhibitors series.
@en
P2093
Anna Rodina
Christopher E Evans
Daniel Gewirth
Hardik J Patel
Maulik Patel
Mohammad Uddin
Pallav D Patel
Smit K Shah
Stefan Ochiana
Tony Taldone
P2860
P304
P356
10.1021/JM400619B
P407
P577
2013-08-21T00:00:00Z