Phosphodiesterase PDE3 blunts the positive inotropic and cyclic AMP enhancing effects of CGP12177 but not of noradrenaline in rat ventricle
about
Inotropy and L-type Ca2+ current, activated by beta1- and beta2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heartFunctional antagonism of β-adrenoceptor subtypes in the catecholamine-induced automatism in rat myocardium.Differential regulation of β2 -adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle.Conserved expression and functions of PDE4 in rodent and human heart.Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (-)-adrenaline mediated through mouse cardiac beta(1)-adrenoceptors.Ontogenic changes of the control by phosphodiesterase-3 and -4 of 5-HT responses in porcine heart and relevance to human atrial 5-HT(4) receptors.5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles.Increased spontaneous activity and reduced inotropic response to catecholamines in ventricular myocytes from footshock-stressed rats.Cardiac PDEs and crosstalk between cAMP and cGMP signalling pathways in the regulation of contractility.
P2860
Q28568207-880E8F14-D6BD-453B-8167-FDC13AA96276Q30498747-39FC5EBF-2DC4-4613-BE4B-1508FB22DDA1Q34449709-F72A7D59-35F8-4AA4-9A12-788794814B6BQ34548139-17E250C1-68FE-43FE-8114-D6414991A74BQ36484604-E6898EB4-2381-48A5-BAA6-0B91C1C9E4E5Q37230983-A39EE747-F341-43AF-8A98-ABDC0F60B4F8Q41139399-031F46A1-C5D7-4B21-A649-9E30F7D51AF9Q43288308-12DCF004-B95D-44C2-B042-1CF4E9B09C1FQ46599816-3491644F-5377-423C-8548-9189B0AF9606
P2860
Phosphodiesterase PDE3 blunts the positive inotropic and cyclic AMP enhancing effects of CGP12177 but not of noradrenaline in rat ventricle
description
2006 nî lūn-bûn
@nan
2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
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2006年论文
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name
Phosphodiesterase PDE3 blunts ...... noradrenaline in rat ventricle
@en
type
label
Phosphodiesterase PDE3 blunts ...... noradrenaline in rat ventricle
@en
prefLabel
Phosphodiesterase PDE3 blunts ...... noradrenaline in rat ventricle
@en
P2093
P2860
P356
P1476
Phosphodiesterase PDE3 blunts ...... noradrenaline in rat ventricle
@en
P2093
Alberto J Kaumann
Jesus Hernandez
Maria Luisa Vargas
P2860
P304
P356
10.1038/SJ.BJP.0706498
P407
P577
2006-01-01T00:00:00Z