GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML.

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Preclinical characterization of therapeutic antibodies targeted at the carboxy-terminus of Sonic hedgehog.

P2860

Q51734236-4846A8CF-E28C-44B8-B28F-0949A1B8C4D7

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GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML.

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http://www.wikidata.org/entity/Q38795323

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年论文

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2017年论文

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2017年论文

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name

GLI3 repressor determines Hedg ...... O antagonist glasdegib in AML.

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type

Item

label

GLI3 repressor determines Hedg ...... O antagonist glasdegib in AML.

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GLI3 repressor determines Hedg ...... O antagonist glasdegib in AML.

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P1476

GLI3 repressor determines Hedg ...... O antagonist glasdegib in AML.

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Akil A Merchant

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Mohan Singh

http://www.w3.org/2001/XMLSchema#string

Monica Guzman

http://www.w3.org/2001/XMLSchema#string

Parvesh Chaudhry

http://www.w3.org/2001/XMLSchema#string

Timothy J Triche

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P2860

Bioconductor: open software development for computational biology and bioinformatics

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Patched acts catalytically to suppress the activity of Smoothened

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning

Developmental roles and clinical significance of hedgehog signaling

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

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3465-3475

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scholarly article

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10.1182/BLOOD-2016-05-718585

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English

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129

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2017-05-09T00:00:00Z

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28487292

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5492089

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GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML.

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P2860

P2860

GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML.

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P2860

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P2093

P2860

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P433

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P932