about
Structural and thermodynamic studies of the interaction of distamycin A with the parallel quadruplex structure [d(TGGGGT)]4Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzleIn silico phosphorylation of the autoinhibited form of p47(phox): insights into the mechanism of activationTargeting G-quadruplex structure in the human c-Kit promoter with short PNA sequences.Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplexSelective Binding of Distamycin A Derivative to G-Quadruplex Structure [d(TGGGGT)](4).Structure and stability insights into tumour suppressor p53 evolutionary related proteins.Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes.Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevanceCross-talk between prion protein and quadruplex-forming nucleic acids: a dynamic complex formation.Applications of isothermal titration calorimetry in biophysical studies of G-quadruplexes.Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis.Ligand binding to telomeric G-quadruplex DNA investigated by funnel-metadynamics simulations.State-of-the-art methodologies for the discovery and characterization of DNA G-quadruplex binders.Noncanonical DNA secondary structures as drug targets: the prospect of the i-motif.Stability and binding properties of a modified thrombin binding aptamer.Fluorescence enhancement upon G-quadruplex folding: synthesis, structure, and biophysical characterization of a dansyl/cyclodextrin-tagged thrombin binding aptamer.Thermodynamics and kinetics of PNA-DNA quadruplex-forming chimeras.Studying the effect of crowding and dehydration on DNA G-quadruplexes.Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment.Cyclodextrin-assisted assembly of PEGylated polyester nanoparticles decorated with folate.Looking for efficient G-quadruplex ligands: evidence for selective stabilizing properties and telomere damage by drug-like molecules.Exploring the chemical space of G-quadruplex binders: discovery of a novel chemotype targeting the human telomeric sequence.Design, synthesis, biophysical and biological studies of trisubstituted naphthalimides as G-quadruplex ligands.Molecular dynamics study of the conformational stability of esterase 2 from Alicyclobacillus acidocaldarius.Differential scanning calorimetry to investigate G-quadruplexes structural stability.Targeting DNA quadruplexes with distamycin A and its derivatives: an ITC and NMR study.Thermodynamic analysis of quadruplex DNA-drug interaction.Binding of Harmine Derivatives to DNA: A Spectroscopic Investigation.Structure of a Stable G-Hairpin.Targeting the BCL2 Gene Promoter G-Quadruplex with a New Class of Furopyridazinone-Based Molecules.Use of NMR in profiling of cocaine seizures.Mutants of the tumour suppressor p53 L1 loop as second-site suppressors for restoring DNA binding to oncogenic p53 mutations: structural and biochemical insightsStability and Cations Coordination of DNA and RNA 14-Mer G-Quadruplexes: A Multiscale Computational ApproachStructural insight into the h TERT intron 6 sequence d(GGGGTGAAAGGGG) from 1H-NMR studyControlled Pore Glass-based oligonucleotide affinity support: towards High Throughput Screening methods for the identification of conformation-selective G-quadruplex ligandsHMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?Characterization of monovarietal extra virgin olive oils from the province of Béjaïa (Algeria)Toward the Development of Specific G-Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives
P50
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P50
description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Bruno Pagano
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Bruno Pagano
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Bruno Pagano
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Bruno Pagano
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Bruno Pagano
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Bruno Pagano
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Bruno Pagano
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Bruno Pagano
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Bruno Pagano
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Bruno Pagano
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Bruno Pagano
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Bruno Pagano
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Bruno Pagano
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Bruno Pagano
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Bruno Pagano
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P106
P1153
9434649100
P21
P2798
P31
P496
0000-0002-7716-9010