Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase.
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Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme IntermediatesCRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention.4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer.The hyaluronic acid inhibitor 4-methylumbelliferone is an NSMase2 activator-role of Ceramide in MU anti-tumor activityA novel role of breast cancer-derived hyaluronan on inducement of M2-like tumor-associated macrophages formation.Targeting hyaluronic acid family for cancer chemoprevention and therapy.Hyaluronan Is Crucial for Stem Cell Differentiation into Smooth Muscle Lineage.Inhibition of hyaluronan synthesis alters sulfated glycosaminoglycans deposition during chondrogenic differentiation in ATDC5 cells.
P2860
Q27675859-236918AE-C3BA-4588-BA23-C8C93A59DD93Q32872051-742A4AA2-3D4B-49C3-BC47-882284DFDA5BQ35206080-339A548F-6C4E-4652-95F9-E04545C2DC82Q36404904-54AE110B-04C3-4F35-87DE-8C5E7D11D327Q37079105-57AC6FC9-E36A-45D3-9E8C-DD33D785E010Q38235792-DF177E01-841A-4BB5-B228-A12D22B5AD4CQ41456041-AC12C09B-C399-443A-A6C5-C206637BB8A3Q50214684-27A1D775-B9A3-4D28-B366-49B06F23F86C
P2860
Reduced chondrogenic matrix accumulation by 4-methylumbelliferone reveals the potential for selective targeting of UDP-glucose dehydrogenase.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Reduced chondrogenic matrix ac ...... of UDP-glucose dehydrogenase.
@en
type
label
Reduced chondrogenic matrix ac ...... of UDP-glucose dehydrogenase.
@en
prefLabel
Reduced chondrogenic matrix ac ...... of UDP-glucose dehydrogenase.
@en
P2093
P2860
P1433
P1476
Reduced chondrogenic matrix ac ...... of UDP-glucose dehydrogenase.
@en
P2093
A A Pitsillides
C E Clarkin
C P Wheeler-Jones
E R Bastow
P2860
P304
P356
10.1016/J.MATBIO.2011.01.002
P577
2011-02-01T00:00:00Z