Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans.
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Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic healthInhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis.Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice.Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans.PPARs and Mitochondrial Metabolism: From NAFLD to HCC.The dark side of the moon: AKT as a tumor suppressor in the liver?TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway.Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma.Inhibition of HSF1 suppresses the growth of hepatocarcinoma cell lines in vitro and AKT-driven hepatocarcinogenesis in mice.ORF3 as a sensitive and specific diagnostic index for hepatitis E.Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells.A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis.Significance and Mechanism of Androgen Receptor (AR) Overexpression and AR-mTOR Crosstalk in Hepatocellular Carcinoma.Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway.Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis.Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer.Small interfering RNA-mediated knockdown of fatty acid synthase attenuates the proliferation and metastasis of human gastric cancer cells via the mTOR/Gli1 signaling pathway.Pterostilbene inhibits nutrient metabolism and induces apoptosis through AMPK activation in multiple myeloma cellsThe role of YAP/TAZ activity in cancer metabolic reprogrammingRole of hepatoma-derived growth factor in promoting de novo lipogenesis and tumorigenesis in hepatocellular carcinoma
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P2860
Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Inactivation of fatty acid syn ...... ven by AKT in mice and humans.
@en
type
label
Inactivation of fatty acid syn ...... ven by AKT in mice and humans.
@en
prefLabel
Inactivation of fatty acid syn ...... ven by AKT in mice and humans.
@en
P2093
P2860
P50
P1476
Inactivation of fatty acid syn ...... ven by AKT in mice and humans.
@en
P2093
Christy Joseph
Chunmei Wang
Diego F Calvisi
Frank Dombrowski
Giulia M Pilo
Lijie Jiang
Maria M Simile
Marta Mela
P2860
P304
P356
10.1016/J.JHEP.2015.10.004
P577
2015-10-14T00:00:00Z