Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation
about
A critical evaluation of PI3K inhibition in Glioblastoma and Neuroblastoma therapyThe relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemiaZebrafish Models of Human Leukemia: Technological Advances and Mechanistic InsightsOptimized cell transplantation using adult rag2 mutant zebrafish.Isolation of the Side Population in Myc-induced T-cell Acute Lymphoblastic Leukemia in Zebrafish.Fusions of Tumor-derived Endothelial Cells with Dendritic Cells Induces Antitumor Immunity.Zebrafish as a model to assess cancer heterogeneity, progression and relapse.Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemiaNormal and malignant muscle cell transplantation into immune compromised adult zebrafish.Preclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer.Impact of PTEN abnormalities on outcome in pediatric patients with T-cell acute lymphoblastic leukemia treated on the MRC UKALL2003 trialImaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish.Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafishT cell immune deficiency in zap70 mutant zebrafishSingle-cell imaging of normal and malignant cell engraftment into optically clear prkdc-null SCID zebrafish.Outlook on PI3K/AKT/mTOR inhibition in acute leukemia.Oncogenic PTEN functions and models in T-cell malignancies.Rictor has a pivotal role in maintaining quiescence as well as stemness of leukemia stem cells in MLL-driven leukemia.Microenvironmental cues for T-cell acute lymphoblastic leukemia development.Leukemic stem cells: identification and clinical application.Zebrafish in Translational Cancer Research: Insight into Leukemia, Melanoma, Glioma and Endocrine Tumor Biology.S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance.Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia.High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia.Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic ProgenitorsPI3Kγ/δ and NOTCH1 Cross-Regulate Pathways That Define the T-cell Acute Lymphoblastic Leukemia Disease Signature.Quo natas, Danio?—Recent Progress in Modeling Cancer in Zebrafish.TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.Quo natas, Danio?-Recent Progress in Modeling Cancer in Zebrafish.Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia.JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.
P2860
Q26849503-A4FCC578-4774-413E-B7AC-1EB62F7C943BQ28075211-E1882833-0F05-47CF-B93C-AB25A50CB8E7Q28078210-1B2CAA0E-5BA6-4002-B66A-0D62CE727CC9Q30615497-B14B684D-37BE-4B6D-8127-9FC53DFF4D8AQ32177143-BECD107E-7542-4B48-9542-616764340832Q33594333-9984F952-5487-46A2-B398-22FC9BD45BDAQ33814223-769654E4-08DA-491D-AED4-B1F2340C8304Q34421363-345A9C40-C8BF-453F-96CC-E640B9F844FBQ35161809-3FA96761-4DFD-4113-A771-35AE249E9EA3Q36378105-C5458492-AC78-4784-9813-509E76B41BC9Q36442504-842A6519-701B-40F1-B16B-CA2AD46348ECQ36528585-44383E3C-CD84-417C-AF67-5FFB72D323D1Q36949940-2E18B8F4-CC7F-4C98-8AE5-679F0D7855C0Q37413647-38C6F98E-4F75-4CE6-92D9-7280B8786EAEQ37415220-9AD25FB9-B05E-4776-8D71-9D09B6A720E0Q38521775-55EEC331-FB09-4BF7-96B1-AA325CB856B6Q38652498-04DC4821-0FBB-4FD1-AC49-9C2C9218A2B9Q38753222-9E0CF9DF-9249-4FBE-8B52-27F5F947841EQ38810904-8E94677E-6D86-4194-9E14-6A5766B0E198Q39208298-1D764FF7-FDFC-4A60-9878-D3A5BEA41388Q41673513-CD4DDEE1-E488-46A0-9F32-CEAB737CFEE3Q41916937-85E9D360-B4A8-4143-AB6B-8A180A15888DQ42369939-E88D8EE0-AF19-4EFB-8BAF-E106CD0960CDQ42733616-E20F8DDD-60C5-40DD-BF6E-C0BA3B98D9AEQ42833446-CD28F7E9-1682-4725-B51D-49DFE37258E1Q46432171-E87DA79C-D675-431A-9A88-EEA935E87589Q47109579-281696EA-35F1-4A03-A110-9325E3B9C01FQ47704064-D00ACD86-2F7B-43C8-A356-3C107924347AQ50143867-AF6E58FF-4B89-4796-8950-7CB8438EE832Q51051812-5E6A0F1C-84A0-4B5E-9926-6D0B9EC29750Q55516451-FA85D04D-6610-4239-8881-310ADDF58DFE
P2860
Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Clonal evolution enhances leuk ...... Akt/mTORC1 pathway activation
@en
type
label
Clonal evolution enhances leuk ...... Akt/mTORC1 pathway activation
@en
prefLabel
Clonal evolution enhances leuk ...... Akt/mTORC1 pathway activation
@en
P2093
P2860
P1433
P1476
Clonal evolution enhances leuk ...... Akt/mTORC1 pathway activation
@en
P2093
Charles Lee
David M Langenau
Eleanor Y Chen
Finola E Moore
Jayme L Wilder
Jessica S Blackburn
Kimberly P Dobrinski
Riadh Lobbardi
Sarah A Martinez
P2860
P304
P356
10.1016/J.CCR.2014.01.032
P577
2014-03-06T00:00:00Z