Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001 - Wikidata - wikimedia - TriplyDB

Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001

Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001

http://www.wikidata.org/entity/Q38843175

about

RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials.Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells.Hypoxic conditions increases H₂S-induced ER stress in A2870 cells.Epigenetic effects of RRx-001: a possible unifying mechanism of anticancer activity.The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry.RRx-001 protects against cisplatin-induced toxicities.Magnetic resonance imaging of RRx-001 pharmacodynamics in preclinical tumors.No patient left behind: The promise of immune priming with epigenetic agents.MIND4-17 protects retinal pigment epithelium cells and retinal ganglion cells from UV.Proteasome-associated deubiquitinases and cancer.MicroRNA-200a activates Nrf2 signaling to protect osteoblasts from dexamethasone.Activation of Nrf2 by MIND4-17 protects osteoblasts from hydrogen peroxide-induced oxidative stress.The dichotomous role of H2S in cancer cell biology? Déjà vu all over again.Activation of AMPK by OSU53 protects spinal cord neurons from oxidative stress.A Review of Clinical Radioprotection and Chemoprotection for Oral Mucositis.

P2860

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P2860

Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001

http://www.wikidata.org/entity/Q38843175

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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name

Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001

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Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001

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Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001

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ONCOTARGET.4249

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Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001

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Bryan Oronsky

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Donna M Peehl

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Jan Scicinski

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Ramasamy Paulmurugan

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Shoucheng Ning

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Susan J Knox

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Thillai Veerapazham Sekar

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P2860

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response e

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents

The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

Discovery of molecular mechanisms of traditional Chinese medicinal formula Si-Wu-Tang using gene expression microarray and connectivity map

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

Preclinical evaluation of the metabolism and disposition of RRx-001, a novel investigative anticancer agent.

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21547-21556

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10.18632/ONCOTARGET.4249

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25

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6

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26280276

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4673285

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