11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice.

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Glucocorticoid Receptor and Adipocyte Biology

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11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice.

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11β-HSD1 Modulates the Set Poi ...... Glucocorticoids in Male Mice.

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11β-HSD1 Modulates the Set Poi ...... Glucocorticoids in Male Mice.

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11β-HSD1 Modulates the Set Poi ...... Glucocorticoids in Male Mice.

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11β-HSD1 Modulates the Set Poi ...... Glucocorticoids in Male Mice.

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11β-HSD1 Modulates the Set Poi ...... Glucocorticoids in Male Mice.

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11β-HSD1 Modulates the Set Poi ...... Glucocorticoids in Male Mice.

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2-s2.0-85020221355

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Endocrinology

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11β-HSD1 Modulates the Set Poi ...... Glucocorticoids in Male Mice.

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P2093

Dean P Larner

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Emma L McCabe

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Gareth G Lavery

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Rachel S Fletcher

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Stuart A Morgan

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P2860

Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes

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Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes

UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency.

11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess

Brown adipose tissue thermogenesis during aging and senescence.

A novel 11β-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits.

A transgenic model of visceral obesity and the metabolic syndrome.

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors still improve metabolic phenotype in male 11β-HSD1 knockout mice suggesting off-target mechanisms.

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1964-1976

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scholarly article

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10.1210/EN.2016-1722

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English

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2017-03-27T00:00:00Z

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1084509016

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83935142

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