Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
about
Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling NetworksCustomizing the genome as therapy for the β-hemoglobinopathiesResources for the design of CRISPR gene editing experimentsA new age in functional genomics using CRISPR/Cas9 in arrayed library screeningEnabling functional genomics with genome engineeringThe CRISPR revolution and its impact on cancer researchGenome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like CellsThe potential for tumor suppressor gene therapy in head and neck cancerCRISPR guide RNA design for research applicationsIdentification of oncogenic driver mutations by genome-wide CRISPR-Cas9 dropout screeningSensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibitionCRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screensBenzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L BromodomainsCRISPR/Cas9: From Genome Engineering to Cancer Drug DiscoveryFlexible CRISPR library construction using parallel oligonucleotide retrieval.CRISPulator: a discrete simulation tool for pooled genetic screensSystematic comparison of CRISPR/Cas9 and RNAi screens for essential genes.Precision cancer mouse models through genome editing with CRISPR-Cas9.Applications of CRISPR technologies in research and beyond.A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.Genome-scale CRISPR-Cas9 knockout and transcriptional activation screeningOptimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9.Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.2C-Cas9: a versatile tool for clonal analysis of gene function.CRISPR library designer (CLD): software for multispecies design of single guide RNA librariesGenome-scale CRISPR pooled screens.Practical Considerations for Using Pooled Lentiviral CRISPR Libraries.High-throughput strategies for the discovery and engineering of enzymes for biocatalysis.EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression.CRISPR/Cas9-The ultimate weapon to battle infectious diseases?Network analysis of gene essentiality in functional genomics experiments.Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool.Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis.Guide Picker is a comprehensive design tool for visualizing and selecting guides for CRISPR experiments.Functional interrogation of non-coding DNA through CRISPR genome editing.Targeting Transcription Factors in CancerNSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.
P2860
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P2860
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
@en
type
label
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
@en
prefLabel
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
@en
P2093
P2860
P356
P1433
P1476
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
@en
P2093
Christopher R Vakoc
Joseph P Milazzo
Junwei Shi
Zihua Wang
P2860
P2888
P304
P356
10.1038/NBT.3235
P577
2015-05-11T00:00:00Z