Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.
about
The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated ProteinsNEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signalingBuilding the Case for Insulin-Like Growth Factor Receptor-I Involvement in Thyroid-Associated Ophthalmopathy.H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis.Ubiquitination and the Regulation of Membrane Proteins.Suppressor of Cytokine Signaling (SOCS)1 Regulates Interleukin-4 (IL-4)-activated Insulin Receptor Substrate (IRS)-2 Tyrosine Phosphorylation in Monocytes and Macrophages via the Proteasome.Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer.IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling.Identification of a novel invasion-promoting region in Insulin Receptor Substrate 2 (IRS2).IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell lineWhole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes
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P2860
Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.
@en
type
label
Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.
@en
prefLabel
Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.
@en
P2093
P2860
P356
P1476
Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity
@en
P2093
Cunming Duan
Fumihiko Hakuno
Haruka Furuta
Hideaki Kamata
Hidehito Yoshihara
Hiroyasu Kamei
Kazuhiro Chida
Keiji Tanaka
Shun-Ichiro Iemura
P2860
P2888
P356
10.1038/NCOMMS7780
P407
P577
2015-04-16T00:00:00Z
P5875
P6179
1052425327