The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor
about
Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advancesMultiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligaseNedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and functionGrb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradationSCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathwayUpregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegenerationNedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cellsUbiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 responseNedd4 controls animal growth by regulating IGF-1 signalingNedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functionsThe ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translationDifferential expression of novel potential regulators in hematopoietic stem cells.The role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancerRegulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteinsTargeting the ubiquitin pathway for cancer treatmentNEDD4: a promising target for cancer therapyStructural Basis for the Interaction between the Growth Factor-binding Protein GRB10 and the E3 Ubiquitin Ligase NEDD4Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodiesG Protein Mono-ubiquitination by the Rsp5 Ubiquitin Ligase.Altered expression and deletion of RMO1 in osteosarcomaThe ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junctionComparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arraysNuclear targeting of IGF-1 receptor in orbital fibroblasts from Graves' disease: apparent role of ADAM17Ubiquitin ligase Nedd4-2 modulates Kv1.3 current amplitude and ion channel protein targetingTissue-specific regulation and function of Grb10 during growth and neuronal commitment.Role of ubiquitination in IGF-1 receptor signaling and degradation.Endocytic regulation of alkali metal transport proteins in mammals, yeast and plants.The UPS in diabetes and obesity.Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc.Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.Alterations in the developing testis transcriptome following embryonic vinclozolin exposureYAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation.Negative regulation of Grb10 Interacting GYF Protein 2 on insulin-like growth factor-1 receptor signaling pathway caused diabetic mice cognitive impairmentType 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells.Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulationThe E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling.Insulin-like growth factor-I E-peptide activity is dependent on the IGF-I receptor.Association study confirmed susceptibility loci with keloid in the Chinese Han population.
P2860
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P2860
The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The Grb10/Nedd4 complex regula ...... -like growth factor I receptor
@ast
The Grb10/Nedd4 complex regula ...... -like growth factor I receptor
@en
The Grb10/Nedd4 complex regula ...... -like growth factor I receptor
@nl
type
label
The Grb10/Nedd4 complex regula ...... -like growth factor I receptor
@ast
The Grb10/Nedd4 complex regula ...... -like growth factor I receptor
@en
The Grb10/Nedd4 complex regula ...... -like growth factor I receptor
@nl
prefLabel
The Grb10/Nedd4 complex regula ...... -like growth factor I receptor
@ast
The Grb10/Nedd4 complex regula ...... -like growth factor I receptor
@en
The Grb10/Nedd4 complex regula ...... -like growth factor I receptor
@nl
P2093
P2860
P921
P3181
P1476
The Grb10/Nedd4 complex regula ...... -like growth factor I receptor
@en
P2093
Adriano Marchese
Andrea Morrione
Pauline Henry
P2860
P304
P3181
P356
10.1128/MCB.23.9.3363-3372.2003
P407
P577
2003-05-01T00:00:00Z