Mutant eIF2B leads to impaired mitochondrial oxidative phosphorylation in vanishing white matter disease.
about
Mitochondrial malfunction in vanishing white matter disease: a disease of the cytosolic translation machinery.EIF2B2 mutations in Vanishing White Matter Disease hyper- suppress translation and delay recovery during the integrated stress response.The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy
P2860
Mutant eIF2B leads to impaired mitochondrial oxidative phosphorylation in vanishing white matter disease.
description
2017 nî lūn-bûn
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name
Mutant eIF2B leads to impaired ...... anishing white matter disease.
@en
type
label
Mutant eIF2B leads to impaired ...... anishing white matter disease.
@en
prefLabel
Mutant eIF2B leads to impaired ...... anishing white matter disease.
@en
P2093
P2860
P356
P1476
Mutant eIF2B leads to impaired ...... anishing white matter disease.
@en
P2093
Andrea Atzmon
Anjana Shenoy
Gali Raini
Melisa Herrero
Reut Sharet
Tamar Geiger
P2860
P304
P356
10.1111/JNC.14024
P407
P577
2017-03-17T00:00:00Z