Astrocytes are central in the pathomechanisms of vanishing white matter - Wikidata - wikimedia - TriplyDB

Astrocytes are central in the pathomechanisms of vanishing white matter

Astrocytes are central in the pathomechanisms of vanishing white matter

http://www.wikidata.org/entity/Q27330146

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A mutation in the Tubb4a gene leads to microtubule accumulation with hypomyelination and demyelination.Mutant eIF2B leads to impaired mitochondrial oxidative phosphorylation in vanishing white matter disease.Endoplasmic Reticulum Protein Quality Control Failure in Myelin Disorders.Leukodystrophies: a proposed classification system based on pathological changes and pathogenetic mechanisms.Stem cell therapy for white matter disorders: don't forget the microenvironment!Simplified 3D protocol capable of generating early cortical neuroepithelium.Enhancement of multiple cranial and spinal nerves in vanishing white matter: expanding the differential diagnosis.Stratification of astrocytes in healthy and diseased brain.Toll-Like Receptor 4 Knockdown Attenuates Brain Damage and Neuroinflammation After Traumatic Brain Injury via Inhibiting Neuronal Autophagy and Astrocyte Activation.Bergmann glia translocation: a new disease marker for vanishing white matter identifies therapeutic effects of Guanabenz treatment.Affected astrocytes in the spinal cord of the leukodystrophy vanishing white matter.Proteomic and Metabolomic Analyses of Vanishing White Matter Mouse Astrocytes Reveal Deregulation of ER Functions.Astrocyte-derived lipocalin-2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia.Axonal abnormalities in vanishing white matter.Adult mouse eIF2Bε Arg191His astrocytes display a normal integrated stress response in vitro.The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.Simultaneous assessment of cognitive function, circadian rhythm, and spontaneous activity in aging mice.Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy

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P2860

Astrocytes are central in the pathomechanisms of vanishing white matter

http://www.wikidata.org/entity/Q27330146

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2016 nî lūn-bûn

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2016 թուականի Մարտին հրատարակուած գիտական յօդուած

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2016 թվականի մարտին հրատարակված գիտական հոդված

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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name

Astrocytes are central in the pathomechanisms of vanishing white matter

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Astrocytes are central in the pathomechanisms of vanishing white matter

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Astrocytes are central in the pathomechanisms of vanishing white matter

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Astrocytes are central in the pathomechanisms of vanishing white matter

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Astrocytes are central in the pathomechanisms of vanishing white matter

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Astrocytes are central in the pathomechanisms of vanishing white matter

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prefLabel

Astrocytes are central in the pathomechanisms of vanishing white matter

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Astrocytes are central in the pathomechanisms of vanishing white matter

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Astrocytes are central in the pathomechanisms of vanishing white matter

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Journal of Clinical Investigation

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Astrocytes are central in the pathomechanisms of vanishing white matter

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Aleid van de Kreeke

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Anne-Lieke F van Deijk

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Caroline Vuong

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Emiel Polder

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Gerbren Jacobs

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Gert C Scheper

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Jan Klooster

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Joke Wortel

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Lisanne E Wisse

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Maarten Kamermans

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P2860

EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy

eIF2B-related disorders: antenatal onset and involvement of multiple organs

Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients

Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients

Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways

Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity

Molecular dissection of reactive astrogliosis and glial scar formation

Cree leukoencephalopathy and CACH/VWM disease are allelic at the EIF2B5 locus

Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter

Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter

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10.1172/JCI83908

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4

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126

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