Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity.
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Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targetingThe lncRNA DRAIC/PCAT29 Locus Constitutes a Tumor-Suppressive Nexus.The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiationClass I lysine deacetylases promote glucocorticoid-induced transcriptional repression through functional interaction with LSD1.The role of GATA2 in lethal prostate cancer aggressiveness.MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators.LSD1: biologic roles and therapeutic targeting.CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer.Integrative genomic analysis in K562 chronic myelogenous leukemia cells reveals that proximal NCOR1 binding positively regulates genes that govern erythroid differentiation and Imatinib sensitivity.Lysine-specific demethylase-1 (LSD1) is compartmentalized at nuclear chromocenters in early post-mitotic cells of the olfactory sensory neuronal lineageThe dual role of LSD1 and HDAC3 in STAT5-dependent transcription is determined by protein interactions, binding affinities, motifs and genomic positions.LSD1 binds to HPV16 E7 and promotes the epithelial-mesenchymal transition in cervical cancer by demethylating histones at the Vimentin promoter.LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer.Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.P110β Inhibition Reduces Histone H3K4 Di-Methylation in Prostate Cancer.Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer.A high definition look at the NF-Y regulome reveals genome-wide associations with selected transcription factors.ERRα induces H3K9 demethylation by LSD1 to promote cell invasion.Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue.Rationale for the development of alternative forms of androgen deprivation therapy.Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer.ERRα protein is stabilized by LSD1 in a demethylation-independent manner.Determining direct binders of the Androgen Receptor using a high-throughput Cellular Thermal Shift Assay.Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis.Targeting oral cancer epigenome via LSD1.LSD1 activates a lethal prostate cancer gene network independently of its demethylase function.LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models.Supraphysiological Testosterone Therapy as Treatment for Castration-Resistant Prostate Cancer.Genetics and biology of prostate cancerPreclinical studies reveal that LSD1 inhibition results in tumor growth arrest in lung adenocarcinoma independently of driver mutations
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P2860
Lysine-specific demethylase 1 has dual functions as a major regulator of androgen receptor transcriptional activity.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh
2014年學術文章
@zh-hant
name
Lysine-specific demethylase 1 ...... ptor transcriptional activity.
@en
type
label
Lysine-specific demethylase 1 ...... ptor transcriptional activity.
@en
prefLabel
Lysine-specific demethylase 1 ...... ptor transcriptional activity.
@en
P2093
P2860
P50
P1433
P1476
Lysine-specific demethylase 1 ...... eptor transcriptional activity
@en
P2093
Eric Metzger
Jesse Zhang
Mei Wei Chen
Roland Schüle
Shaoyong Chen
Steven P Balk
X Shirley Liu
Yanfei Gao
P2860
P304
P356
10.1016/J.CELREP.2014.11.008
P577
2014-12-04T00:00:00Z