Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody
about
Embelin binds to human neuroserpin and impairs its polymerisation.An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding.The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization.Evaluation of Alpha-1 Antitrypsin Levels and SERPINA1 Gene Polymorphisms in Sickle Cell Disease.Probing the folding pathway of a consensus serpin using single tryptophan mutants.
P2860
Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody
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name
Characterising the association ...... ng a novel monoclonal antibody
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type
label
Characterising the association ...... ng a novel monoclonal antibody
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prefLabel
Characterising the association ...... ng a novel monoclonal antibody
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P2093
P2860
P50
P1476
Characterising the association ...... ng a novel monoclonal antibody
@en
P2093
Adriana Ordóñez
David A Lomas
Dawn L DeMeo
Elena Miranda
Farshid N Rouhani
Graeme J M Alexander
Jennifer A Dickens
Juan Perez
Keith A Burling
P2860
P356
10.1016/J.BIOCEL.2014.11.005
P577
2014-11-13T00:00:00Z