Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.
about
Recent developments in drug discovery for leishmaniasis and human African trypanosomiasisPlasticity of the Leishmania genome leading to gene copy number variations and drug resistanceContribution of high-content imaging technologies to the development of anti-infective drugsINsPECT, an open-source and versatile software for automated quantification of (Leishmania) intracellular parasitesHigh throughput screening for anti-Trypanosoma cruzi drug discoveryInfrared fluorescent imaging as a potent tool for in vitro, ex vivo and in vivo models of visceral leishmaniasisAntiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug RepositioningDevelopment and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade.High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoniNew compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.Antileishmanial Activity of Compounds Derived from the Medicines for Malaria Venture Open Access Box Against Intracellular Leishmania major AmastigotesDevelopment and validation of a high-throughput anti-Wolbachia whole-cell screen: a route to macrofilaricidal drugs against onchocerciasis and lymphatic filariasis.High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.Unravelling the rate of action of hits in the Leishmania donovani box using standard drugs amphotericin B and miltefosineAntileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichumA Replicative In Vitro Assay for Drug Discovery against Leishmania donovaniOvercoming the challenges of drug discovery for neglected tropical diseases: the A·WOL experience.Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.The development of high-content screening (HCS) technology and its importance to drug discovery.Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.Snapshot Profiling of the Antileishmanial Potency of Lead Compounds and Drug Candidates against Intracellular Leishmania donovani Amastigotes, with a Focus on Human-Derived Host Cells.Development of a semi-automated image-based high-throughput drug screening system.Leishmania and other intracellular pathogens: selectivity, drug distribution and PK-PD.Marine Algae as Source of Novel Antileishmanial Drugs: A Review.Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening.A complex interplay between sphingolipid and sterol metabolism revealed by perturbations to the Leishmania metabolome caused by miltefosine.Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform.Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles.Autophagic-related cell death of Trypanosoma brucei induced by bacteriocin AS-48.Innovation in neglected tropical disease drug discovery and development.Challenges in drug discovery targeting TriTryp diseases with an emphasis on leishmaniasisImportance of secondary screening with clinical isolates for anti-leishmania drug discoveryDevelopment of an automated image analysis protocol for quantification of intracellular forms of Leishmania sppAntitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition MetalsSynthesis of carboxyimidamide-substituted benzo[c][1,2,5]oxadiazoles and their analogs, and evaluation of biological activity against Leishmania donovani
P2860
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P2860
Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Comparison of a high-throughpu ...... th an axenic amastigote assay.
@en
type
label
Comparison of a high-throughpu ...... th an axenic amastigote assay.
@en
prefLabel
Comparison of a high-throughpu ...... th an axenic amastigote assay.
@en
P2093
P2860
P50
P356
P1476
Comparison of a high-throughpu ...... th an axenic amastigote assay.
@en
P2093
Dhananjay Joshi
Irene Hallyburton
John Thomas
Julie A Frearson
Lorna Campbell
P2860
P304
P356
10.1128/AAC.02398-12
P407
P577
2013-04-09T00:00:00Z