Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen
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Kinases as druggable targets in trypanosomatid protozoan parasitesRecent developments in drug discovery for leishmaniasis and human African trypanosomiasisAn image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophagesAdvances in Development of New Treatment for LeishmaniasisA target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activityAntileishmanial high-throughput drug screening reveals drug candidates with new scaffoldsA screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hitIdentification of new antileishmanial leads from hits obtained by high-throughput screeningHigh content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discoveryCharacterization of a Novel Endoplasmic Reticulum Protein Involved in Tubercidin Resistance in Leishmania majorAntiparasitic lethality of sulfonamidebenzamides in kinetoplastids.Drug discovery algorithm for cutaneous leishmaniasis.Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical diseaseA novel Leishmania major amastigote assay in 96-well format for rapid drug screening and its use for discovery and evaluation of a new class of leishmanicidal quinolinium salts.Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.Imaging flow cytometry analysis of intracellular pathogens.DETC-based bacterial cellulose bio-curatives for topical treatment of cutaneous leishmaniasis.Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it?Antileishmanial Activity of Disulfiram and Thiuram Disulfide Analogs in an Ex Vivo Model System Is Selectively Enhanced by the Addition of Divalent Metal Ions.Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.Development of an ex vivo lymph node explant model for identification of novel molecules active against Leishmania major.Transgenic parasites accelerate drug discoveryCalcium Ionophore, Calcimycin, Kills Leishmania Promastigotes by Activating Parasite Nitric Oxide Synthase.Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening.Arginine and Polyamines Fate in Leishmania Infection.Development of an automated image analysis protocol for quantification of intracellular forms of Leishmania spp
P2860
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P2860
Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Identification of potent chemo ...... nhanced, small molecule screen
@ast
Identification of potent chemo ...... nhanced, small molecule screen
@en
Identification of potent chemo ...... nhanced, small molecule screen
@nl
type
label
Identification of potent chemo ...... nhanced, small molecule screen
@ast
Identification of potent chemo ...... nhanced, small molecule screen
@en
Identification of potent chemo ...... nhanced, small molecule screen
@nl
prefLabel
Identification of potent chemo ...... nhanced, small molecule screen
@ast
Identification of potent chemo ...... nhanced, small molecule screen
@en
Identification of potent chemo ...... nhanced, small molecule screen
@nl
P2093
P2860
P50
P3181
P1476
Identification of potent chemo ...... nhanced, small molecule screen
@en
P2093
Alan J Magill
David Close
Gabriela Mustata
Jacob Johnson
Michael O'Neil
Robyn Reed
Tongying Shun
P2860
P3181
P356
10.1371/JOURNAL.PNTD.0000540
P407
P577
2009-11-03T00:00:00Z