Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.
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Chikungunya vaccines in developmentEfficacy of T-705 (Favipiravir) in the Treatment of Infections with Lethal Severe Fever with Thrombocytopenia Syndrome VirusAlterations in favipiravir (T-705) pharmacokinetics and biodistribution in a hamster model of viral hemorrhagic fever.Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68.Low-dose ribavirin potentiates the antiviral activity of favipiravir against hemorrhagic fever virusesAntiviral Activity of Favipiravir (T-705) against a Broad Range of Paramyxoviruses In Vitro and against Human Metapneumovirus in Hamsters.The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection.In Vitro Assessment of Combinations of Enterovirus Inhibitors against Enterovirus 71The Antiviral Alkaloid Berberine Reduces Chikungunya Virus-Induced Mitogen-Activated Protein Kinase Signaling.Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses.Extinction of West Nile virus by Favipiravir through lethal mutagenesis.Chikungunya virus: recent advances in epidemiology, host pathogen interaction and vaccine strategies.Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism.Biochemical Evaluation of the Inhibition Properties of Favipiravir and 2'-C-Methyl-Cytidine Triphosphates against Human and Mouse Norovirus RNA Polymerases.Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.Chikungunya Virus.Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase.Chikungunya infection in a human immunodeficiency virus-infected kidney transplant recipient returning to Italy from the Dominican Republic.Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase.Synthesis of T-705-Ribonucleoside and T-705-Ribonucleotide and Studies of Chemical Stability.Reverse Genetics Approaches for Chikungunya Virus.Antiviral Strategies Against Chikungunya Virus.A compendium of small molecule direct-acting and host-targeting inhibitors as therapies against alphaviruses.β-D-N(4)-hydroxycytidine is a potent anti-alphavirus compound that induces high level of mutations in viral genome.Chikungunya: vaccines and therapeutics.Nonstructural Proteins of Alphavirus-Potential Targets for Drug Development.Current Strategies for Inhibition of Chikungunya Infection.Favipiravir (T-705) protects against Nipah virus infection in the hamster model.Differential Transmission of Antiviral Drug-Resistant Chikungunya Viruses by MosquitoesThe mechanism of resistance to favipiravir in influenzaPeptide vaccine against chikungunya virus: immuno-informatics combined with molecular docking approach
P2860
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P2860
Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.
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2014 nî lūn-bûn
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name
Mutations in the chikungunya v ...... ), a broad-spectrum antiviral.
@en
type
label
Mutations in the chikungunya v ...... ), a broad-spectrum antiviral.
@en
prefLabel
Mutations in the chikungunya v ...... ), a broad-spectrum antiviral.
@en
P2093
P50
P356
P1476
Mutations in the chikungunya v ...... ), a broad-spectrum antiviral.
@en
P2093
Boris Pastorino
Byron Martina
Felio Bello
Kai Dallmeier
Mathy Froeyen
Nidya Segura Guerrero
P304
P356
10.1093/JAC/DKU209
P407
P50
P577
2014-06-20T00:00:00Z