about
Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agentDifluoromethylbenzoxazole pyrimidine thioether derivatives: a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitorsDrug candidates and model systems in respiratory syncytial virus antiviral drug discoveryPatients with discordant responses to antiretroviral therapy have impaired killing of HIV-infected T cells.Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.A novel high-throughput cellular screening assay for the discovery of HIV-1 integrase inhibitors.Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease.Novel HIV-1 reverse transcriptase inhibitors.Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity.Formation of a quaternary complex of HIV-1 reverse transcriptase with a nucleotide-competing inhibitor and its ATP enhancer.Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors".Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitorsAntiviral Activity of Favipiravir (T-705) against a Broad Range of Paramyxoviruses In Vitro and against Human Metapneumovirus in Hamsters.The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection.The viral polymerase inhibitor 2'-C-methylcytidine inhibits Norwalk virus replication and protects against norovirus-induced diarrhea and mortality in a mouse model.Intervention strategies for emerging viruses: use of antivirals.Norovirus: targets and tools in antiviral drug discovery.Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1.Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.The enterovirus protease inhibitor rupintrivir exerts cross-genotypic anti-norovirus activity and clears cells from the norovirus replicon.Rapid and convenient assays to assess potential inhibitory activity on in vitro hepatitis A replication.A novel kindred with inherited STAT2 deficiency and severe viral illness.Prophylactic treatment with the nucleoside analogue 2'-C-methylcytidine completely prevents transmission of norovirus.Antiviral treatment efficiently inhibits chikungunya virus infection in the joints of mice during the acute but not during the chronic phase of the infection.MAPPIT as a high-throughput screening assay for modulators of protein-protein interactions in HIV and HCV.Mannitol treatment is not effective in therapy of rabies virus infection in mice.The path towards effective antivirals against rabies.Bicyclic and Tricyclic "Expanded" Nucleobase Analogues of Sofosbuvir: New Scaffolds for Hepatitis C Therapies.Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones.Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium.Pyrimethamine inhibits rabies virus replication in vitroProgress in human picornavirus research: New findings from the AIROPico consortiumDifferential Antiviral Activities of RSV Inhibitors in Human Airway EpitheliumA novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPEInherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccinesNew HSV-1 Anti-Viral 1'-Homocarbocyclic Nucleoside Analogs with an Optically Active Substituted Bicyclo[2.2.1]Heptane Fragment as a Glycoside MoietyA novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses
P50
Q24656023-C3B75E02-3C42-49D8-A9A5-B86C8DE43AC9Q27675153-C321BF24-13F4-4E32-8FAB-B6A1BFC90292Q28066429-70913C9B-8D27-40DD-824B-E9B055B44E84Q33760825-A527F702-EC41-493C-8726-13B981A337C6Q34058365-C6E1B3CC-3209-4B78-A6F6-A7AAE11BAB22Q34102270-A7AFF59B-02A7-4AF6-8250-B9DDEB00FD96Q34282609-650B25BC-EA76-455D-9DA8-351192D81695Q34756615-95FC52FC-76DD-4282-837E-060B1CC9B9BCQ35739055-06993B16-B528-428F-BD03-B31266D56627Q36928993-A07FF04F-5C0D-4C1E-87FA-7EC4F19C9CFBQ36949351-60E8E0FC-A4DD-4BF9-AF11-5089E51D3526Q36949688-22D6744B-1EBA-421A-9817-F1979461041AQ37120083-D19557E9-E77B-4223-B3FD-CEEC5722ED45Q37193248-45F2AA6B-3D25-44A0-8C21-7C6D66AF0BCDQ37252661-7364446E-ED5C-455B-843F-F0F0AAB162FDQ38096721-EEF45ABA-D744-4F4A-9366-4A949E734122Q38217316-C303CA68-E28C-4D9E-AC5B-16757DCF1D26Q38723435-6EC9545D-A6FE-4407-BABC-B01226F1DC9BQ38982527-5F66DDA5-3E53-4BF4-947E-B81E837C068FQ38988957-65F95790-2765-40A7-B82F-789AF025354FQ39175865-8E9B29FB-E012-4423-B45E-B99765E560EAQ40372366-DD581780-BA23-479D-BD4E-319442F38CBAQ41736599-EB6EB059-5EAD-49E8-934E-679762225257Q41928409-70FDBABD-8815-4AD4-A8F2-0C6D31732262Q43046991-483FA3DE-B081-4825-B7BD-42735717EFFCQ47254286-1C1C4418-100B-4798-915D-8EF284F57E47Q47560386-ED944747-091C-47CF-89E3-0EC94116B3FFQ49048945-7DF05FBD-7DCB-4817-8CDB-68134A9210C0Q50182085-EA52B7AC-84B5-4B75-BC18-D70AB64B105DQ55400300-E5F506B5-1130-43D6-89A4-3EF942702021Q58117975-9A53362E-7A9D-42EF-A251-823577C1286FQ59350186-9F7450A5-7C77-4516-AD54-2980343450CEQ60220815-CDB731DA-86D1-4F5E-A596-ECC9E8657040Q60220915-9FB92E37-EC44-41C9-9748-8C6F7C73252CQ91593468-A0F972B2-F907-4653-B883-60F312CC5CB8Q91657183-E1276D8F-0379-45E2-A2CF-51B772C11847Q92656973-7EA8E221-BE3B-4C94-A5D0-B7DC5BAC444A
P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Dirk Jochmans
@ast
Dirk Jochmans
@en
Dirk Jochmans
@es
Dirk Jochmans
@nl
type
label
Dirk Jochmans
@ast
Dirk Jochmans
@en
Dirk Jochmans
@es
Dirk Jochmans
@nl
altLabel
DIRK JOCHMANS
@en
prefLabel
Dirk Jochmans
@ast
Dirk Jochmans
@en
Dirk Jochmans
@es
Dirk Jochmans
@nl
P214
P1053
T-6223-2017
P106
P1153
15136256700
P214
P31
P496
0000-0002-9265-6028