Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo.

Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo.

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http://www.wikidata.org/entity/Q39002694
A novel, somatic, transforming mutation in the extracellular domain of Epidermal Growth Factor Receptor identified in myeloproliferative neoplasm.NT113, a pan-ERBB inhibitor with high brain penetrance, inhibits the growth of glioblastoma xenografts with EGFR amplification.Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells.LINC01225 promotes occurrence and metastasis of hepatocellular carcinoma in an epidermal growth factor receptor-dependent pathway.Genetic biomarkers of drug response for small-molecule therapeutics targeting the RTK/Ras/PI3K, p53 or Rb pathway in glioblastoma.Investigational new drugs for brain cancer.Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The "Rotation Model".Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma.Molecular Correlates of In Vitro Responses to Dacomitinib and Afatinib in Bladder Cancer.Cyclic trans-phosphorylation in a homodimer as the predominant mechanism of EGFRvIII action and regulation.A Pre-Clinical Assessment of the Pan-ERBB Inhibitor Dacomitinib in Pediatric and Adult Brain Tumors.
P2860

Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo.

Item
http://www.wikidata.org/entity/Q39002694
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Glioma-specific Domain IV EGFR ...... tivity to dacomitinib in vivo.
@en
Glioma-specific Domain IV EGFR ...... tivity to dacomitinib in vivo.
@nl
type
label
Glioma-specific Domain IV EGFR ...... tivity to dacomitinib in vivo.
@en
Glioma-specific Domain IV EGFR ...... tivity to dacomitinib in vivo.
@nl
prefLabel
Glioma-specific Domain IV EGFR ...... tivity to dacomitinib in vivo.
@en
Glioma-specific Domain IV EGFR ...... tivity to dacomitinib in vivo.
@nl
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P6179
P698
P356
P1433
P1476
Glioma-specific Domain IV EGFR ...... tivity to dacomitinib in vivo.
@en
P2093
P2860
P2888
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P6179
P698