Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models. - Wikidata - wikimedia - TriplyDB

Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models.

Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models.

http://www.wikidata.org/entity/Q39021475

about

Hepatitis B virus therapy: What's the future holding for us?Modulation of Protein-Protein Interactions for the Development of Novel Therapeutics Small-molecule SMAC mimetics as new cancer therapeutics Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma Correlating chemical sensitivity and basal gene expression reveals mechanism of action.NCTD promotes Birinapant-mediated anticancer activity in breast cancer cells by downregulation of c-FLIP.Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus.Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis Combination effects of SMAC mimetic birinapant with TNFα, TRAIL, and docetaxel in preclinical models of HNSCC.Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis.Diffusion-weighted MRI for imaging cell death after cytotoxic or apoptosis-inducing therapy.An apoptosis-enhancing drug overcomes platinum resistance in a tumour-initiating subpopulation of ovarian cancer.Mechanism-based mathematical modeling of combined gemcitabine and birinapant in pancreatic cancer cells.IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis.PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition Pharmacodynamic markers and clinical results from the phase 2 study of the SMAC mimetic birinapant in women with relapsed platinum-resistant or -refractory epithelial ovarian cancer.Effect of a Smac Mimetic (TL32711, Birinapant) on the Apoptotic Program and Apoptosis Biomarkers Examined with Validated Multiplex Immunoassays Fit for Clinical Use.Patient-derived glioblastoma cells show significant heterogeneity in treatment responses to the inhibitor-of-apoptosis-protein antagonist birinapant Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia.Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic.A dual role for Caspase8 and NF-κB interactions in regulating apoptosis and necroptosis of ovarian cancer, with correlation to patient survival ApoCanD: Database of human apoptotic proteins in the context of cancer.Future therapy for hepatitis B virus infection.IAP Antagonists Enhance Apoptotic Response to Enzalutamide in Castration-Resistant Prostate Cancer Cells via Autocrine TNF-α Signaling.SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2.Targeting Programmed Cell Death Using Small-Molecule Compounds to Improve Potential Cancer Therapy.Electrophilic Oxidation and [1,2]-Rearrangement of the Biindole Core of Birinapant.Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death Pathways.NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis.Bivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-κB signaling by degrading TRAF2-associated cIAP1 in cancer cells.Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells.Bivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-κB signaling IAP antagonization promotes inflammatory destruction of vascular endothelium.SMAC Mimetic BV6 Enables Sensitization of Resistant Tumor Cells but also Affects Cytokine-Induced Killer (CIK) Cells: A Potential Challenge for Combination Therapy.PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy.TRAF2 in osteotropic breast cancer cells enhances skeletal tumour growth and promotes osteolysis.Temporal Effects of Combined Birinapant and Paclitaxel on Pancreatic Cancer Cells Investigated via Large-scale, Ion-Current-Based Quantitative Proteomics (IonStar).Clinicopathological and functional implications of the inhibitor of apoptosis proteins survivin and XIAP in esophageal cancer.

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P2860

Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models.

http://www.wikidata.org/entity/Q39021475

description

2014 nî lūn-bûn

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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2014年论文

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name

Birinapant (TL32711), a bivale ...... ient-derived xenograft models.

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Birinapant (TL32711), a bivale ...... ient-derived xenograft models.

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type

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Birinapant (TL32711), a bivale ...... ient-derived xenograft models.

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Birinapant (TL32711), a bivale ...... ient-derived xenograft models.

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Birinapant (TL32711), a bivale ...... ient-derived xenograft models.

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Birinapant (TL32711), a bivale ...... ient-derived xenograft models.

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Molecular Cancer Therapeutics

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Birinapant (TL32711), a bivale ...... ient-derived xenograft models.

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Christopher A Benetatos

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David Weng

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Eric M Neiman

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Guangyao Yu

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Gurpreet S Kapoor

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Jennifer M Burns

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Mark A McKinlay

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Martin E Seipel

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Matthew D Alexander

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