Bivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-κB signaling

about

Bivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-κB signaling

Item

http://www.wikidata.org/entity/Q41432435

description

2016 nî lūn-bûn

@nan

2016年の論文

@ja

2016年論文

@yue

2016年論文

@zh-hant

2016年論文

@zh-hk

2016年論文

@zh-mo

2016年論文

@zh-tw

2016年论文

@wuu

2016年论文

@zh

2016年论文

@zh-cn

name

Bivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-κB signaling

@en

type

Item

label

Bivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-κB signaling

@en

prefLabel

Bivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-κB signaling

@en

P1476

Bivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-κB signaling

@en

P2093

Stephen M Condon

http://www.w3.org/2001/XMLSchema#string

P2860

Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

IAP inhibitors enhance co-stimulation to promote tumor immunity.

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.

Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis.

An apoptosis-enhancing drug overcomes platinum resistance in a tumour-initiating subpopulation of ovarian cancer.

Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models.

Characterization of ML-IAP protein stability and physiological role in vivo.

Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL.

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

P304

e2385

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/CDDIS.2016.283

http://www.w3.org/2001/XMLSchema#string

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P577

2016-09-29T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

27685629

http://www.w3.org/2001/XMLSchema#string

P921

NF-κB

P932

5059881

http://www.w3.org/2001/XMLSchema#string