Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling. - Wikidata - wikimedia - TriplyDB

Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling.

Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling.

http://www.wikidata.org/entity/Q39094389

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Not so Fast: Co-Requirements for Sonic Hedgehog Induced Brain Tumorigenesis Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1 Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity Oncogenic BRAFV600E induces expression of neuronal differentiation marker MAP2 in melanoma cells by promoter demethylation and down-regulation of transcription repressor HES1.NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma.Notch signaling in glioblastoma: a developmental drug target?Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells.Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors.Targeting Hedgehog--a cancer stem cell pathway Notch signaling is not essential in sonic hedgehog-activated medulloblastoma.Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis.RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer.Molecular conversations and the development of the hair follicle and basal cell carcinoma.The different role of Notch1 and Notch2 in astrocytic gliomas Canonical Notch signalling is inactive in urothelial carcinoma.The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance.Role of Notch and its oncogenic signaling crosstalk in breast cancer.HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumors Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells.A BAC transgenic Hes1-EGFP reporter reveals novel expression domains in mouse embryos.Investigational Notch and Hedgehog inhibitors--therapies for cardiovascular disease.Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells.Persistent expression of activated notch in the developing hypothalamus affects survival of pituitary progenitors and alters pituitary structure.Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications in medulloblastoma.Patterning and compartment formation in the diencephalon.Hes1: a key role in stemness, metastasis and multidrug resistance.Joint interpretation of AER/FGF and ZPA/SHH over time and space underlies hairy2 expression in the chick limb.Notch/Rbpjκ signaling regulates progenitor maintenance and differentiation of hypothalamic arcuate neurons A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma Epigenetic silencing of miRNA-9 is associated with HES1 oncogenic activity and poor prognosis of medulloblastoma.Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals Role of Notch signaling pathway in pancreatic cancer.Targeting Notch signaling in pancreatic cancer.Notch signalling pathway in tooth development and adult dental cells.Targeting the Hedgehog signaling pathway for cancer therapy.

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P2860

Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling.

http://www.wikidata.org/entity/Q39094389

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Sonic Hedgehog regulates Hes1 ...... ical Notch pathway signalling.

@en

Sonic Hedgehog regulates Hes1 ...... ical Notch pathway signalling.

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type

label

Sonic Hedgehog regulates Hes1 ...... ical Notch pathway signalling.

@en

Sonic Hedgehog regulates Hes1 ...... ical Notch pathway signalling.

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prefLabel

Sonic Hedgehog regulates Hes1 ...... ical Notch pathway signalling.

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Sonic Hedgehog regulates Hes1 ...... ical Notch pathway signalling.

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Sonic Hedgehog regulates Hes1 ...... nical Notch pathway signalling

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A R Hallahan

http://www.w3.org/2001/XMLSchema#string

B J Wainwright

http://www.w3.org/2001/XMLSchema#string

K I McCue

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T H Tran

http://www.w3.org/2001/XMLSchema#string

P2860

TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

HERP, a new primary target of Notch regulated by ligand binding

Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Notch signaling: from the outside in

HES and HERP families: multiple effectors of the Notch signaling pathway

Identification of sonic hedgehog-responsive genes using cDNA microarray

Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation

P2888

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1489-1500

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scholarly article

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10.1038/SJ.ONC.1210767

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10

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27

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Wendy J. Ingram

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2007-09-17T00:00:00Z

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5968877

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17873912

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