RUNX3 interacts with MYCN and facilitates protein degradation in neuroblastoma.

about

NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas Nifurtimox reduces N-Myc expression and aerobic glycolysis in neuroblastoma.Roles of RUNX in Solid Tumors.

P2860

Q21092404-ACF74233-71AF-4A5E-B565-D4A8380FAAEC Q36212750-93206E33-8326-47F1-86F1-B78990F57724 Q50796410-EC51B958-AE11-46A7-B9AE-2CAFD316F19E

P2860

RUNX3 interacts with MYCN and facilitates protein degradation in neuroblastoma.

Item

http://www.wikidata.org/entity/Q39126205

description

2013 nî lūn-bûn

@nan

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

RUNX3 interacts with MYCN and facilitates protein degradation in neuroblastoma.

@en

RUNX3 interacts with MYCN and facilitates protein degradation in neuroblastoma.

@nl

type

Item

label

RUNX3 interacts with MYCN and facilitates protein degradation in neuroblastoma.

@en

RUNX3 interacts with MYCN and facilitates protein degradation in neuroblastoma.

@nl

prefLabel

RUNX3 interacts with MYCN and facilitates protein degradation in neuroblastoma.

@en

RUNX3 interacts with MYCN and facilitates protein degradation in neuroblastoma.

@nl

P1476

RUNX3 interacts with MYCN and facilitates protein degradation in neuroblastoma.

@en

P2093

A Nakagawara

http://www.w3.org/2001/XMLSchema#string

F Yu

http://www.w3.org/2001/XMLSchema#string

K Ando

http://www.w3.org/2001/XMLSchema#string

M Ohira

http://www.w3.org/2001/XMLSchema#string

T Yokochi

http://www.w3.org/2001/XMLSchema#string

W Gao

http://www.w3.org/2001/XMLSchema#string

Y Nakamura

http://www.w3.org/2001/XMLSchema#string

P2860

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3

Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets

Causal relationship between the loss of RUNX3 expression and gastric cancer

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53.

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.

Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line.

Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins.

Myc proteins as therapeutic targets.

P2888

onc.2013.221

P304

2601-2609

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/ONC.2013.221

http://www.w3.org/2001/XMLSchema#string

P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Yusuke Suenaga

P577

2013-07-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

23851507

http://www.w3.org/2001/XMLSchema#string

RUNX3 interacts with MYCN and facilitates protein degradation in neuroblastoma.

about

P2860

P2860

RUNX3 interacts with MYCN and facilitates protein degradation in neuroblastoma.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P407

P433

P478

P50

P577

P698

P356

P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P407

P433

P478

P50

P577

P698