Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. - Wikidata - wikimedia - TriplyDB

Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.

Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.

http://www.wikidata.org/entity/Q39126224

about

Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-kappa B, and Akt in normal and malignant human mesothelial cells Ankrd2/ARPP is a novel Akt2 specific substrate and regulates myogenic differentiation upon cellular exposure to H(2)O(2)Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction Switching Akt: from survival signaling to deadly response AKT/PKB signaling: navigating downstream Status of PI3K/Akt/mTOR pathway inhibitors in lymphoma Microglia are mediators of Borrelia burgdorferi-induced apoptosis in SH-SY5Y neuronal cells Maximising the potential of AKT inhibitors as anti-cancer treatments Low-Concentration Arsenic Trioxide Inhibits Skeletal Myoblast Cell Proliferation via a Reactive Oxygen Species-Independent Pathway Characterization of the Akt2 domain essential for binding nuclear p21cip1 to promote cell cycle arrest during myogenic differentiation The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration Cytoplasmic localization of p21 protects trophoblast giant cells from DNA damage induced apoptosis.Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors.Signaling specificity in the Akt pathway in biology and disease.Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells.Lactoferrin deficiency promotes colitis-associated colorectal dysplasia in mice.Cytoplasmic p21 is a potential predictor for cisplatin sensitivity in ovarian cancer Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease.Signalling pathways in endometrial cancer Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer Platinum resistance in breast and ovarian cancer cell lines Oxidation of Akt2 kinase promotes cell migration and regulates G1-S transition in the cell cycle.Akt2 kinase suppresses glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-mediated apoptosis in ovarian cancer cells via phosphorylating GAPDH at threonine 237 and decreasing its nuclear translocation Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance.Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity.Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration.Akt2 knock-down reveals its contribution to human lung cancer cell proliferation, growth, motility, invasion and endothelial cell tube formation Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo.Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice Structural and Biophysical Characterization of the Interactions between Calmodulin and the Pleckstrin Homology Domain of Akt.Tumorigenesis and peritoneal colonization from fallopian tube epithelium.Identification of functional domains in AKT responsible for distinct roles of AKT isoforms in pressure-stimulated cancer cell adhesion.The eIF4E RNA regulon promotes the Akt signaling pathway.Achieving specificity in Akt signaling in cancer.Vitronectin improves cell survival after radiation injury in human umbilical vein endothelial cells Intracellular targets for a phosphotyrosine peptidomimetic include the mitotic kinesin, MCAK Biomarkers of response to Akt inhibitor MK-2206 in breast cancer Differential regulation of the histone chaperone HIRA during muscle cell differentiation by a phosphorylation switch.Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle

P2860

Q23917646-330B2BE2-1FF1-4025-ADEE-29678DF7CDB1 Q24311740-032B7882-7D1A-4A8D-A2B5-BE9F93959B6A Q24602385-53D272D8-E30D-4BFE-9132-827AEE360687 Q24632379-71A22497-C405-4D1E-9944-4B0AD5D639EE Q24657857-39DFF2A5-3729-4F72-8A5B-16388E7A5D22 Q27026544-D10B4162-D361-4FA4-932F-ED2E678E9345 Q27316104-344399F0-96F3-46BA-B58C-4241E103CCFA Q28072254-24927C45-BB30-4A37-ABD2-73A850700A32 Q28388442-7890754F-0F1D-4075-BF27-71681674E5DA Q28534602-B85B7E55-EF13-4EAB-B55F-F135BDE4DA46 Q30494570-890F4F5A-84B6-4C7B-881A-D53DE202D4E1 Q33644593-7D5EF6B5-9D3D-4CF0-894C-057B118F6ABA Q33737298-26F3EC08-9ECA-411B-8A7D-C566CEF3E96F Q33770769-26864E34-8903-4D8A-A73E-481EDC05E28D Q33775212-07E92FCD-F371-4098-A2F0-706709F2585D Q33812880-E732EBB2-4B41-4015-A05A-25B7AA1249AA Q33946055-73FDC2B5-176F-405D-904F-36A24EDFBBDA Q34024735-EE2EDC15-D897-4048-9F1B-6F54906C5A59 Q34150587-161D70D4-4245-4567-B692-0AC6A01317EC Q34721660-40B74168-E2DE-4E27-AB48-F00B28F88625 Q35151491-D9A5BC36-8322-4D0D-8921-6E233DE78316 Q35397906-603799BF-EB23-4D46-B5A9-57CB5710ED06 Q35600738-DBCB1848-6E9A-4991-AB02-89934CD3E22A Q35604944-F6716F77-05B0-4415-B393-1C77A1BDFED2 Q35674559-2AD2E80E-F73B-4C9E-962F-029D28BEF6C1 Q35748395-F4447859-908F-47D4-99C1-25EAD87E1D74 Q35830233-5371066A-D4C2-457A-8978-8EB6F2C45427 Q35909804-BA2955C0-E649-430B-8A47-BE43BDE0B01F Q35921170-CDF8230D-C1C8-4DB4-B6E7-099B8F8756EA Q36196806-DA41047E-8AD2-43F4-A9F9-50C280A5826A Q36283948-C31A6F40-A3B6-4F20-9BC4-92DBAC8D4339 Q36299733-E0AD871F-1BC8-49E6-86D2-B2A0D99D8856 Q36334336-D20698B1-B117-420E-82D0-E25299AE7F5D Q36527188-DE28043D-1A0C-42DA-A184-AD0519B686C8 Q36733736-4FA9B6FF-9E41-404E-AE3F-174371F5FF08 Q36917473-578B0B41-56AC-4D2B-B1DC-F3724DC1459B Q37127445-D7B6FC0C-B19F-4E6A-AA4D-E470341D1093 Q37168778-BE4A093B-4512-4FE0-BDAE-903343362296 Q37223761-D3B2AD25-BD22-49CC-B7FC-759A2D643565 Q37244654-48E76DF2-519B-4923-A974-0BCC3BF3B5FF

P2860

Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.

http://www.wikidata.org/entity/Q39126224

description

2006 nî lūn-bûn

@nan

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

2006年论文

@zh

2006年论文

@zh-cn

name

Only Akt1 is required for prol ...... ycle exit through p21 binding.

@en

Only Akt1 is required for prol ...... ycle exit through p21 binding.

@nl

type

label

Only Akt1 is required for prol ...... ycle exit through p21 binding.

@en

Only Akt1 is required for prol ...... ycle exit through p21 binding.

@nl

prefLabel

Only Akt1 is required for prol ...... ycle exit through p21 binding.

@en

Only Akt1 is required for prol ...... ycle exit through p21 binding.

@nl

P1433

Q39126224-978274F1-2E75-479D-B339-EDB03E7F2DC1

P1476

Q39126224-2255204C-5BD2-4B7C-A273-EB0EE6FC6BB1

P2093

Q39126224-31FC3699-A69F-4162-B965-19052A5B3956

Q39126224-502332DD-7717-435B-8F1A-44084670F1D2

Q39126224-8AA093A4-D209-44D0-AFE0-4933280E99E2

Q39126224-A26106AA-B886-419D-AD3F-4856A2037934

Q39126224-C6AA1B00-38C3-4E1E-94E1-FC3D6B032BEC

Q39126224-E6257359-677D-4DC7-9717-B87EC8C39D5E

P2860

Q39126224-05EAE714-2015-467F-9A1B-53F195971A32

Q39126224-092730C4-B1CA-4977-92C5-DA72F8A941CC

Q39126224-0CDEF5FE-DABC-451D-9A63-443D6349DA66

Q39126224-1D43815A-EA24-4957-8899-707004FDB519

Q39126224-1ED18AC0-D92F-4B25-9688-F718A0BDE872

Q39126224-24FBC746-EA72-41F5-8226-537885122767

Q39126224-26D9EDA4-7177-4D6E-A621-25C7AA608381

Q39126224-27BE5961-F217-4754-99B6-A7D9E52515A1

Q39126224-3F4AC9F2-1239-4E9D-85A3-71DCE278A77B

Q39126224-404693FB-0E1F-4E4A-BA5B-1ADB95A183C8

P304

Q39126224-6533D2FE-969A-4D49-9CB4-11253B887B8D

P31

Q39126224-A1E41662-F002-41E4-9352-786837381DE1

P356

Q39126224-C12AD1EC-B609-4145-B6F6-1344B0AABEAC

P407

Q39126224-CD7BEFA8-8E81-439E-8D21-5E7EF65A7FC7

P433

Q39126224-2F726155-B4B8-48AB-BA08-C3FB70DA4840

P478

Q39126224-48D58606-762E-4A65-A3F4-35AD2B6A055A

P50

Q39126224-0BAD9564-9CFB-4A88-8DA3-15B3D9DBCFB5

Q39126224-484301BD-01D3-4859-9972-F85D1285BC64

P577

Q39126224-0CDB142F-ED97-4BDF-9914-3D4DF6D38895

P698

Q39126224-7CE99EC9-A5E6-40C4-8485-DDCDB982400D

P932

Q39126224-5BDF28BB-F5F0-4FC4-9D70-CF9F9667F9C7

P356

P1433

Molecular and Cellular Biology

P1476

Only Akt1 is required for prol ...... cycle exit through p21 binding

@en

P2093

Anne Fernandez

http://www.w3.org/2001/XMLSchema#string

Brian A Hemmings

http://www.w3.org/2001/XMLSchema#string

Celine Franckhauser

http://www.w3.org/2001/XMLSchema#string

Cyril Berthenet

http://www.w3.org/2001/XMLSchema#string

Ned J C Lamb

http://www.w3.org/2001/XMLSchema#string

Vanessa Rana

http://www.w3.org/2001/XMLSchema#string

P2860

Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases

Mechanism of activation of protein kinase B by insulin and IGF-1

Cyclin-binding motifs are essential for the function of p21CIP1

Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy

Protein kinase B alpha/Akt1 regulates placental development and fetal growth

P304

8267-8280

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/MCB.00201-06

http://www.w3.org/2001/XMLSchema#string

P407

P433

22

http://www.w3.org/2001/XMLSchema#string

P478

26

http://www.w3.org/2001/XMLSchema#string

P50

Lisa Heron-Milhavet

P577

2006-09-18T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

16982699

http://www.w3.org/2001/XMLSchema#string

P932

1636765

http://www.w3.org/2001/XMLSchema#string