DDX3 loss by p53 inactivation promotes tumor malignancy via the MDM2/Slug/E-cadherin pathway and poor patient outcome in non-small-cell lung cancer. - Wikidata - wikimedia - TriplyDB

DDX3 loss by p53 inactivation promotes tumor malignancy via the MDM2/Slug/E-cadherin pathway and poor patient outcome in non-small-cell lung cancer.

DDX3 loss by p53 inactivation promotes tumor malignancy via the MDM2/Slug/E-cadherin pathway and poor patient outcome in non-small-cell lung cancer.

http://www.wikidata.org/entity/Q39166828

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Multifunctional DDX3: dual roles in various cancer development and its related signaling pathways DDX3, a potential target for cancer treatment The YAP1/SIX2 axis is required for DDX3-mediated tumor aggressiveness and cetuximab resistance in KRAS-wild-type colorectal cancer.Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer.Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.DDX3X Biomarker Correlates with Poor Survival in Human Gliomas The Clinical and Pathological Significance of Nectin-2 and DDX3 Expression in Pancreatic Ductal Adenocarcinomas.Ezrin Binds to DEAD-Box RNA Helicase DDX3 and Regulates Its Function and Protein Level.The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription DDX3 as a strongest prognosis marker and its downregulation promotes metastasis in colorectal cancer.Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer DDX3 Represses Stemness by Epigenetically Modulating Tumor-suppressive miRNAs in Hepatocellular Carcinoma.DDX3 enhances oncogenic KRAS‑induced tumor invasion in colorectal cancer via the β‑catenin/ZEB1 axis.RNA helicase DDX3 maintains lipid homeostasis through upregulation of the microsomal triglyceride transfer protein by interacting with HNF4 and SHP.The prognostic effect of DDX3 upregulation in distant breast cancer metastases.Slug expression in mouse skin and skin tumors is not regulated by p53.Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection.Establishment of basal cell carcinoma animal model in Chinese tree shrew (Tupaia belangeri chinensis).RK-33 Radiosensitizes Prostate Cancer Cells by Blocking the RNA Helicase DDX3 Curcumin Inhibits Invasiveness and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Through Reducing Matrix Metalloproteinase 2, 9 and Modulating p53-E-Cadherin Pathway.Wanted DEAD/H or Alive: Helicases Winding Up in Cancers.Phosphorylation of paxillin confers cisplatin resistance in non-small cell lung cancer via activating ERK-mediated Bcl-2 expression.RNA helicase DDX3: a novel therapeutic target in Ewing sarcoma.Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma.Identification of recurrent truncated DDX3X mutations in chronic lymphocytic leukaemia.DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.Influence of MDM2 SNP309 and SNP285 status on the risk of cancer in the breast, prostate, lung and colon.MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells.FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction.Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis.Effects of MDM2 promoter polymorphisms on the development of cervical neoplasia in a Southeastern Brazilian population.LKB1 loss at transcriptional level promotes tumor malignancy and poor patient outcomes in colorectal cancer.[Effects of tumor suppressor gene TCF21 on the proliferation, migration and apoptosis of A549 cells].The RNA Helicase DDX6 Associates with RIG-I to Augment Induction of Antiviral Signaling RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma Abnormal expression of YEATS4 associates with poor prognosis and promotes cell proliferation of hepatic carcinoma cell by regulation the TCEA1/DDX3 axis

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DDX3 loss by p53 inactivation promotes tumor malignancy via the MDM2/Slug/E-cadherin pathway and poor patient outcome in non-small-cell lung cancer.

http://www.wikidata.org/entity/Q39166828

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2013 nî lūn-bûn

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name

DDX3 loss by p53 inactivation ...... in non-small-cell lung cancer.

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DDX3 loss by p53 inactivation ...... in non-small-cell lung cancer.

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type

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DDX3 loss by p53 inactivation ...... in non-small-cell lung cancer.

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DDX3 loss by p53 inactivation ...... in non-small-cell lung cancer.

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DDX3 loss by p53 inactivation ...... in non-small-cell lung cancer.

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DDX3 loss by p53 inactivation ...... in non-small-cell lung cancer.

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DDX3 loss by p53 inactivation ...... in non-small-cell lung cancer.

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C-Y Chen

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D-W Wu

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J Wang

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P2860

DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor

DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control

p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma

Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene

Twist and p53 reciprocally regulate target genes via direct interaction

Mdm2 promotes the rapid degradation of p53

Epithelial-mesenchymal transitions in tumour progression

Regulation of p53 stability by Mdm2

The snail superfamily of zinc-finger transcription factors

Papillomaviruses and cancer: from basic studies to clinical application

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