Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance.
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Recent Advances in the Trichomonas vaginalis FieldNew drug target in protozoan parasites: the role of thioredoxin reductaseDrug Resistance in the Microaerophilic Parasite Giardia lambliaFunctional characterization of peroxiredoxins from the human protozoan parasite Giardia intestinalisBenznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomicsIntra-subtype variation in enteroadhesion accounts for differences in epithelial barrier disruption and is associated with metronidazole resistance in Blastocystis subtype-7Biochemistry and evolution of anaerobic energy metabolism in eukaryotesTrichomoniasis - are we giving the deserved attention to the most common non-viral sexually transmitted disease worldwide?Natural Products as New Treatment Options for Trichomoniasis: A Molecular Docking Investigation.Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.Deficiency of the ferrous iron transporter FeoAB is linked with metronidazole resistance in Bacteroides fragilis.Trichomonas vaginalis flavin reductase 1 and its role in metronidazole resistance.Transcriptomic identification of iron-regulated and iron-independent gene copies within the heavily duplicated Trichomonas vaginalis genome.A new-generation 5-nitroimidazole can induce highly metronidazole-resistant Giardia lamblia in vitro.Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lambliaIn vitro trichomonacidal activity and preliminary in silico chemometric studies of 5-nitroindazolin-3-one and 3-alkoxy-5-nitroindazole derivatives.Down-regulation of flavin reductase and alcohol dehydrogenase-1 (ADH1) in metronidazole-resistant isolates of Trichomonas vaginalisPeroxiredoxins in parasites.Getting trichy: tools and approaches to interrogating Trichomonas vaginalis in a post-genome worldComparative characterisation of two nitroreductases from Giardia lamblia as potential activators of nitro compounds.Gradual neofunctionalization in the convergent evolution of trichomonad lactate and malate dehydrogenases.Evaluation of Giardia lamblia thioredoxin reductase as drug activating enzyme and as drug target.The effect of the disulfideisomerase domain containing protein in the defense against polyhexamethylene biguanide of highly tolerant Acanthamoeba at the trophozoite stage.Trichomonas vaginalis metronidazole resistance is associated with single nucleotide polymorphisms in the nitroreductase genes ntr4Tv and ntr6Tv.Trichomonas vaginalis: Clinical relevance, pathogenicity and diagnosis.Epigenetics regulates transcription and pathogenesis in the parasite Trichomonas vaginalis.A study on Nim expression in Bacteroides fragilis.Nitroimidazole drugs vary in their mode of action in the human parasite Giardia lamblia.Entamoeba histolytica: identification of thioredoxin-targeted proteins and analysis of serine acetyltransferase-1 as a prototype example.Maximizing bactericidal activity with combinations of bioreduced drugs.Bi-functionalization of a calcium phosphate-coated titanium surface with slow-release simvastatin and metronidazole to provide antibacterial activities and pro-osteodifferentiation capabilities.An Efficient One-Pot Catalyzed Synthesis of 2,4-Disubstituted 5-Nitroimidazoles Displaying Antiparasitic and Antibacterial Activities.Genetic Indicators of Drug Resistance in the Highly Repetitive Genome of Trichomonas vaginalis.Auranofin inactivates Trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo.Divergent Transcriptional Responses to Physiological and Xenobiotic Stress in Giardia duodenalis.Eicosapentaenoic Acid Modulates Trichomonas vaginalis Activity.The FAD-dependent glycerol-3-phosphate dehydrogenase of Giardia duodenalis: an unconventional enzyme that interacts with the g14-3-3 and it is a target of the antitumoral compound NBDHEX.Metabolism of nitro drugs metronidazole and nitazoxanide in Giardia lamblia: characterization of a novel nitroreductase (GlNR2).Potential of bisbenzimidazole-analogs toward metronidazole-resistant Trichomonas vaginalis isolates.A review on metronidazole: an old warhorse in antimicrobial chemotherapy.
P2860
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P2860
Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Trichomonas vaginalis: metroni ...... azole toxicity and resistance.
@en
Trichomonas vaginalis: metroni ...... azole toxicity and resistance.
@nl
type
label
Trichomonas vaginalis: metroni ...... azole toxicity and resistance.
@en
Trichomonas vaginalis: metroni ...... azole toxicity and resistance.
@nl
prefLabel
Trichomonas vaginalis: metroni ...... azole toxicity and resistance.
@en
Trichomonas vaginalis: metroni ...... azole toxicity and resistance.
@nl
P2093
P2860
P50
P1476
Trichomonas vaginalis: metroni ...... dazole toxicity and resistance
@en
P2093
David Leitsch
Johannes Stadlmann
Marina Binder
P2860
P304
P356
10.1111/J.1365-2958.2009.06675.X
P407
P577
2009-04-01T00:00:00Z