Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence. - Wikidata - wikimedia - TriplyDB

Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence.

Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence.

http://www.wikidata.org/entity/Q39170489

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Wnt5a Signaling in Cancer Replication Stress: A Lifetime of Epigenetic Change The FHIT gene product: tumor suppressor and genome "caretaker"The multiple connections between pRB and cell metabolism Two-way communication between the metabolic and cell cycle machineries: the molecular basis In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells.Undercover: gene control by metabolites and metabolic enzymes HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells.Nucleotide metabolism, oncogene-induced senescence and cancer.The role of senescent cells in ageing.Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance.TAp73 promotes anti-senescence-anabolism not proliferation.Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation BRAF mutation is associated with a specific cell type with features suggestive of senescence in ovarian serous borderline (atypical proliferative) tumors Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress.NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation.Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer.SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.S phase block following MEC1ATR inactivation occurs without severe dNTP depletion.Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization.The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia.Targeting the Warburg effect in cancer cells through ENO1 knockdown rescues oxidative phosphorylation and induces growth arrest Replication stress and cancer: it takes two to tango.From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence.Vitamin D/vitamin D receptor axis regulates DNA repair during oncogene-induced senescence.Apoptotic transition of senescent cells accompanied with mitochondrial hyper-function.BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity.Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity Gene expression signature based screening identifies ribonucleotide reductase as a candidate therapeutic target in Ewing sarcoma.Drug-induced premature senescence model in human dental follicle stem cells.Chromatin maintenance and dynamics in senescence: a spotlight on SAHF formation and the epigenome of senescent cells.Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.Replication initiation and genome instability: a crossroads for DNA and RNA synthesis.NF-Y activates genes of metabolic pathways altered in cancer cells.Deoxyribonucleotide metabolism, mutagenesis and cancer.

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P2860

Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence.

http://www.wikidata.org/entity/Q39170489

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

Suppression of nucleotide meta ...... f oncogene-induced senescence.

@en

Suppression of nucleotide meta ...... f oncogene-induced senescence.

@nl

type

label

Suppression of nucleotide meta ...... f oncogene-induced senescence.

@en

Suppression of nucleotide meta ...... f oncogene-induced senescence.

@nl

prefLabel

Suppression of nucleotide meta ...... f oncogene-induced senescence.

@en

Suppression of nucleotide meta ...... f oncogene-induced senescence.

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J.CELREP.2013.03.004

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Suppression of nucleotide meta ...... f oncogene-induced senescence.

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Azat Garipov

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Benjamin G Bitler

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Gao Zhang

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Hong Wu

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Hua Li

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Katherine M Aird

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Rugang Zhang

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Zhi Wei

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Zhigang Tu

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P2860

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Molecular dissection of formation of senescence-associated heterochromatin foci

Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

Cellular senescence: when bad things happen to good cells

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

BRAFE600-associated senescence-like cell cycle arrest of human naevi

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1252-1265

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10.1016/J.CELREP.2013.03.004

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4

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3

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Meenhard Herlyn

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2013-04-04T00:00:00Z

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236126894

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3840499

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