Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation. - Wikidata - wikimedia - TriplyDB

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation.

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation.

http://www.wikidata.org/entity/Q39177084

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Repurposing metformin: an old drug with new tricks in its binding pockets An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment "Inflammaging" as a Druggable Target: A Senescence-Associated Secretory Phenotype-Centered View of Type 2 Diabetes Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks Controls of Nuclear Factor-Kappa B Signaling Activity by 5'-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells Extracellular microRNAs and endothelial hyperglycaemic memory: a therapeutic opportunity?Antioxidant and Anti-Senescence Effect of Metformin on Mouse Olfactory Ensheathing Cells (mOECs) May Be Associated with Increased Brain-Derived Neurotrophic Factor Levels-An Ex Vivo Study.To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway.Tackling the tumor microenvironment: what challenge does it pose to anticancer therapies?JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization Involvement of metformin and AMPK in the radioresponse and prognosis of luminal versus basal-like breast cancer treated with radiotherapy Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity.Mutant lamin A links prophase to a p53 independent senescence program.MLL1 is essential for the senescence-associated secretory phenotype Tetraploidization or autophagy: The ultimate fate of senescent human endometrial stem cells under ATM or p53 inhibition Potential applications for biguanides in oncology Metformin: do we finally have an anti-aging drug?Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence.Senescent cells: SASPected drivers of age-related pathologies.Tumour suppressors and cellular senescence.Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction.Metformin as a Tool to Target Aging.Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?Emerging links among Chromosome Instability (CIN), cancer, and aging.The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging.A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling Cellular senescence in renal ageing and disease.Metformin: New Preparations and Nonglycemic Benefits.The female reproduction and senescence nexus.Nutrient sensing pathways as therapeutic targets for healthy ageing.Cellular Senescence: A Translational Perspective.Senescent cells: an emerging target for diseases of ageing.A phenotype of IGFBP-3 knockout mice revealed by dextran sulfate-induced colitis.Metformin attenuates lung fibrosis development via NOX4 suppression.Effect of Metformin, Rapamycin, and Their Combination on Growth and Progression of Prostate Tumors in HiMyc Mice.p21(WAF1/CIP1) Expression is Differentially Regulated by Metformin and Rapamycin.Metformin, aging and cancer.Quantitative and Systems Pharmacology 3. Network-Based Identification of New Targets for Natural Products Enables Potential Uses in Aging-Associated Disorders.

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P2860

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation.

http://www.wikidata.org/entity/Q39177084

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

Metformin inhibits the senesce ...... ing with IKK/NF-κB activation.

@en

Metformin inhibits the senesce ...... ing with IKK/NF-κB activation.

@nl

type

label

Metformin inhibits the senesce ...... ing with IKK/NF-κB activation.

@en

Metformin inhibits the senesce ...... ing with IKK/NF-κB activation.

@nl

prefLabel

Metformin inhibits the senesce ...... ing with IKK/NF-κB activation.

@en

Metformin inhibits the senesce ...... ing with IKK/NF-κB activation.

@nl

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Metformin inhibits the senesce ...... ing with IKK/NF-κB activation.

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P2093

Alexandra E Cadar

http://www.w3.org/2001/XMLSchema#string

Emmanuelle St-Germain

http://www.w3.org/2001/XMLSchema#string

Geneviève Huot

http://www.w3.org/2001/XMLSchema#string

Gerardo Ferbeyre

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Michael N Pollak

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Olga Moiseeva

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Sebastian Igelmann

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Véronique Bourdeau

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P2860

Clinical Pharmacokinetics of Metformin

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

DNA damage-mediated induction of a chemoresistant niche

Motif module map reveals enforcement of aging by continual NF-kappaB activity

Investigating metformin for cancer prevention and treatment: the end of the beginning

Reconstructing eukaryotic NAD metabolism

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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489-498

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scholarly article

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10.1111/ACEL.12075

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3

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12

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Xavier Deschênes-Simard

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2013-04-23T00:00:00Z

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236073723

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23521863

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