Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity - Wikidata - wikimedia - TriplyDB

Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity

Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity

http://www.wikidata.org/entity/Q39200573

about

Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization Differential activation of CC chemokine receptors by AOP-RANTES Viral entry through CXCR4 is a pathogenic factor and therapeutic target in human immunodeficiency virus type 1 disease Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis Hsc/Hsp70 interacting protein (hip) associates with CXCR2 and regulates the receptor signaling and trafficking Spontaneous and antigen-induced production of HIV-inhibitory beta-chemokines are associated with AIDS-free status Immuno-pathomechanism of liver fibrosis: targeting chemokine CCL2-mediated HIV:HCV nexus Structural and functional studies of the potent anti-HIV chemokine variant P2-RANTES The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity Structure-function relationship between the human chemokine receptor CXCR3 and its ligands A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity Variable sensitivity of CCR5-tropic human immunodeficiency virus type 1 isolates to inhibition by RANTES analogs HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties Potent, broad-spectrum inhibition of human immunodeficiency virus type 1 by the CCR5 monoclonal antibody PRO 140 Identification and characterization of ZEL-H16 as a novel agonist of the histamine H3 receptor C-terminal engineering of CXCL12 and CCL5 chemokines: functional characterization by electrophysiological recordings Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies Peptide and protein-based inhibitors of HIV-1 co-receptors Flat clathrin lattices: stable features of the plasma membrane.Multiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies.Human immunodeficiency virus type 1 entry inhibitors selected on living cells from a library of phage chemokines.Enhancement of the HIV-1 inhibitory activity of RANTES by modification of the N-terminal region: dissociation from CCR5 activation.A new mouse model for female genital schistosomiasis.HIV coreceptors, cell tropism and inhibition by chemokine receptor ligands.Will multiple coreceptors need to be targeted by inhibitors of human immunodeficiency virus type 1 entry?Highly potent RANTES analogues either prevent CCR5-using human immunodeficiency virus type 1 infection in vivo or rapidly select for CXCR4-using variants.Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5 Chemokine receptor trafficking and viral replication.Emerging concepts and approaches for chemokine-receptor drug discovery.Use of inhibitors to evaluate coreceptor usage by simian and simian/human immunodeficiency viruses and human immunodeficiency virus type 2 in primary cells.Chemokine receptor oligomerization and allostery.Donor- and ligand-dependent differences in C-C chemokine receptor 5 reexpression.Human immunodeficiency virus type 1 (HIV-1)-induced GRO-alpha production stimulates HIV-1 replication in macrophages and T lymphocytes Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Highly potent inhibition of human immunodeficiency virus type 1 replication by TAK-220, an orally bioavailable small-molecule CCR5 antagonist.Resistance to the CCR5 inhibitor 5P12-RANTES requires a difficult evolution from CCR5 to CXCR4 coreceptor use.Simian immunodeficiency virus infection alters chemokine networks in lung tissues of cynomolgus macaques: association with Pneumocystis carinii infection.

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Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity

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P2860

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

Identification of a major co-receptor for primary isolates of HIV-1

RANTES and MCP-3 antagonists bind multiple chemokine receptors

The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

Expression cloning of new receptors used by simian and human immunodeficiency viruses

Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection

A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors

Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates

CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1

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