Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells.

Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells.

Item
http://www.wikidata.org/entity/Q39226526
Homozygous mdm2 SNP309 cancer cells with compromised transcriptional elongation at p53 target genes are sensitive to induction of p53-independent cell death.Triptolide has anticancer and chemosensitization effects by down-regulating Akt activation through the MDM2/REST pathway in human breast cancer.MDM2's social network.Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination.Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication.Multipoint targeting of the PI3K/mTOR pathway in mesothelioma.The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing.The p53/mouse double minute 2 homolog complex deregulation in merlin-deficient tumours.MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter.p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a.A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo.
P2860

Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells.

Item
http://www.wikidata.org/entity/Q39226526
description
2012 nî lūn-bûn
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2012年の論文
@ja
2012年論文
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2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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2012年论文
@zh
2012年论文
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name
Human oncoprotein MDM2 activat ...... val advantage to cancer cells.
@en
Human oncoprotein MDM2 activat ...... val advantage to cancer cells.
@nl
type
label
Human oncoprotein MDM2 activat ...... val advantage to cancer cells.
@en
Human oncoprotein MDM2 activat ...... val advantage to cancer cells.
@nl
prefLabel
Human oncoprotein MDM2 activat ...... val advantage to cancer cells.
@en
Human oncoprotein MDM2 activat ...... val advantage to cancer cells.
@nl
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P433
P478
P50
P577
P698
P932
P356
P1433
P1476
Human oncoprotein MDM2 activat ...... ival advantage to cancer cells
@en
P2093
P2860
P2888
P304
P31
P356
P433
P478
P50
P577
P698
P932