Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
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RBB, a novel transcription repressor, represses the transcription of HDM2 oncogeneTip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiationEffects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neckMDM2 regulates dihydrofolate reductase activity through monoubiquitinationATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damageCancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradationThe role of the ubiquitination-proteasome pathway in breast cancer: use of mouse models for analyzing ubiquitination processesMechanisms of impaired differentiation in rhabdomyosarcomaMolecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple MyelomaRole of MDM2 and MDMX in DNA repairDysregulation of ubiquitin ligases in cancerCombined effects of MDM2 SNP309 and TP53 R72P polymorphisms, and soy isoflavones on breast cancer risk among Chinese women in SingaporeIdentification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents adriamycin and actinomycin DA novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2MDM2 and HIF1alpha expression levels in different histologic subtypes of malignant pleural mesothelioma: correlation with pathological and clinical data.Therapeutic efficacy of p53 restoration in Mdm2-overexpressing tumors.Regulation of p53 stability.Controlling the Mdm2-Mdmx-p53 Circuit.The p53 orchestra: Mdm2 and Mdmx set the toneThe Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.Molecular insight into medulloblastoma and central nervous system primitive neuroectodermal tumor biology from hereditary syndromes: a review.Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4MDM2, MDMX and p53 in oncogenesis and cancer therapyLimiting the power of p53 through the ubiquitin proteasome pathway.Natural product ginsenoside 25-OCH3-PPD inhibits breast cancer growth and metastasis through down-regulating MDM2.Decreased Mdm2 expression inhibits tumor development and extends survival independent of Arf and dependent on p53.Protein-protein interactions for cancer therapyMDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis.p53 gene mutation and MDM2 overexpression in a case of primary malignant fibrous histiocytoma of the jejunum.A small nuclear RNA, hdm365, is the major processing product of the human mdm2 gene.Differential expression of arrestins is a predictor of breast cancer progression and survival.Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expressionStress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct waysMDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cellsPhosphorylation of serine 18 regulates distinct p53 functions in miceHuman MDM2 isoforms translated differentially on constitutive versus p53-regulated transcripts have distinct functions in the p53/MDM2 and TSG101/MDM2 feedback control loops.Mouse double minute-2 homolog (MDM2)-rs2279744 polymorphism associated with lung cancer risk in a Northeastern Chinese population.Antisense approaches in prostate cancer.Comparison of hepatocellular carcinoma in American and Asian patients by tissue array analysisDeveloping genetically engineered mouse models to study tumor suppression.
P2860
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P2860
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
@ast
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
@en
type
label
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
@ast
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
@en
prefLabel
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
@ast
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
@en
P2093
P2860
P356
P1476
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.
@en
P2093
A R Hancock
L A Donehower
P2860
P304
15608-15612
P356
10.1073/PNAS.95.26.15608
P407
P577
1998-12-01T00:00:00Z