Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. - Wikidata - wikimedia - TriplyDB

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.

http://www.wikidata.org/entity/Q33601591

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RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck MDM2 regulates dihydrofolate reductase activity through monoubiquitination ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation The role of the ubiquitination-proteasome pathway in breast cancer: use of mouse models for analyzing ubiquitination processes Mechanisms of impaired differentiation in rhabdomyosarcoma Molecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple Myeloma Role of MDM2 and MDMX in DNA repair Dysregulation of ubiquitin ligases in cancer Combined effects of MDM2 SNP309 and TP53 R72P polymorphisms, and soy isoflavones on breast cancer risk among Chinese women in Singapore Identification and characterization of a novel Mdm2 splice variant acutely induced by the chemotherapeutic agents adriamycin and actinomycin D A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2 MDM2 and HIF1alpha expression levels in different histologic subtypes of malignant pleural mesothelioma: correlation with pathological and clinical data.Therapeutic efficacy of p53 restoration in Mdm2-overexpressing tumors.Regulation of p53 stability.Controlling the Mdm2-Mdmx-p53 Circuit.The p53 orchestra: Mdm2 and Mdmx set the tone The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.Molecular insight into medulloblastoma and central nervous system primitive neuroectodermal tumor biology from hereditary syndromes: a review.Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4 MDM2, MDMX and p53 in oncogenesis and cancer therapy Limiting the power of p53 through the ubiquitin proteasome pathway.Natural product ginsenoside 25-OCH3-PPD inhibits breast cancer growth and metastasis through down-regulating MDM2.Decreased Mdm2 expression inhibits tumor development and extends survival independent of Arf and dependent on p53.Protein-protein interactions for cancer therapy MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis.p53 gene mutation and MDM2 overexpression in a case of primary malignant fibrous histiocytoma of the jejunum.A small nuclear RNA, hdm365, is the major processing product of the human mdm2 gene.Differential expression of arrestins is a predictor of breast cancer progression and survival.Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression Stress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct ways MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells Phosphorylation of serine 18 regulates distinct p53 functions in mice Human MDM2 isoforms translated differentially on constitutive versus p53-regulated transcripts have distinct functions in the p53/MDM2 and TSG101/MDM2 feedback control loops.Mouse double minute-2 homolog (MDM2)-rs2279744 polymorphism associated with lung cancer risk in a Northeastern Chinese population.Antisense approaches in prostate cancer.Comparison of hepatocellular carcinoma in American and Asian patients by tissue array analysis Developing genetically engineered mouse models to study tumor suppression.

P2860

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P2860

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.

http://www.wikidata.org/entity/Q33601591

description

1998 nî lūn-bûn

@nan

1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

1998年の論文

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1998年論文

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1998年論文

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1998年論文

@zh-hk

1998年論文

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1998年論文

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1998年论文

@wuu

name

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.

@ast

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.

@en

type

label

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.

@ast

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.

@en

prefLabel

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.

@ast

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.

@en

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Proceedings of the National Academy of Sciences of the United States of America

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Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis.

@en

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A Bradley

http://www.w3.org/2001/XMLSchema#string

A R Hancock

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H Vogel

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L A Donehower

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S N Jones

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P2860

Mdm2 promotes the rapid degradation of p53

Interaction between the retinoblastoma protein and the oncoprotein MDM2

Regulation of p53 stability by Mdm2

Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas

Amplification of a gene encoding a p53-associated protein in human sarcomas

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

The p53-mdm-2 autoregulatory feedback loop

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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