β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease. - Wikidata - wikimedia - TriplyDB

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease.

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease.

http://www.wikidata.org/entity/Q39234405

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Gpr3 stimulates Aβ production via interactions with APP and β-arrestin2 G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRs Trafficking regulation of proteins in Alzheimer's disease Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?Glutathione and mitochondria The Subcellular Dynamics of the Gs-Linked Receptor GPR3 Contribute to the Local Activation of PKA in Cerebellar Granular Neurons Complex regulation of γ-secretase: from obligatory to modulatory subunits Regulation of amyloid precursor protein processing by serotonin signaling An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease.Corticotropin-releasing factor overexpression gives rise to sex differences in Alzheimer's disease-related signaling.Arrestins contribute to amyloid beta-induced cell death via modulation of autophagy and the α7nAch receptor in SH-SY5Y cells.Targeting psychologic stress signaling pathways in Alzheimer's disease.A tricyclic antidepressant, amoxapine, reduces amyloid-β generation through multiple serotonin receptor 6-mediated targets.Prediction of miRNA-mRNA associations in Alzheimer's disease mice using network topology.ARRB1/β-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia.Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice.FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells.OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin.Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains.Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity.Construction and analysis of the protein-protein interaction networks based on gene expression profiles of Parkinson's disease.The stress response neuropeptide CRF increases amyloid-β production by regulating γ-secretase activity Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology.Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand.Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue Dopamine D2 receptor and β-arrestin 2 mediate Amyloid-β elevation induced by anti-parkinson's disease drugs, levodopa and piribedil, in neuronal cells Locus Coeruleus, norepinephrine and Aβ peptides in Alzheimer's disease Analyzing the role of receptor internalization in the regulation of melanin-concentrating hormone signaling.Interaction of membrane/lipid rafts with the cytoskeleton: impact on signaling and function: membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling.Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking.Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments.Structural biology of presenilins and signal peptide peptidases.Targeting ubiquilin-1 in Alzheimer's disease.Development and mechanism of γ-secretase modulators for Alzheimer's disease.β-Arrestins as potential therapeutic targets for Alzheimer's disease.Novel disease-modifying therapeutics for the treatment of Alzheimer's disease.Advances in quantitative structure-activity relationship models of anti-Alzheimer's agents.Allosteric and biased g protein-coupled receptor signaling regulation: potentials for new therapeutics.

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β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease.

http://www.wikidata.org/entity/Q39234405

description

2012 nî lūn-bûn

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2012年论文

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2012年论文

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2012年论文

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name

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease.

@en

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease.

@nl

type

label

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease.

@en

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease.

@nl

prefLabel

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease.

@en

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease.

@nl

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Nature Medicine

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β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease.

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P2093

Amantha Thathiah

http://www.w3.org/2001/XMLSchema#string

An Snellinx

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Elke Vandewyer

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Gerdien De Kloe

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Katrien Horré

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Marta Ciesielska

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Sebastian Munck

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Yunhong Huang

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P2860

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

A beta-arrestin 2 signaling complex mediates lithium action on behavior

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

The G protein-coupled receptor repertoires of human and mouse

Tau-targeted treatment strategies in Alzheimer's disease

Neuropathological stageing of Alzheimer-related changes

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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43-49

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10.1038/NM.3023

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1

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19

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Bart De Strooper

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2012-12-02T00:00:00Z

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233828607

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1006374095

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23202293

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Alzheimer's disease