Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.
about
Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrierSolution structure analysis of cytoplasmic domain of podocyte protein Neph1 using small/wide angle x-ray scattering (SWAXS)SIRPα interacts with nephrin at the podocyte slit diaphragmDirect regulation of nephrin tyrosine phosphorylation by Nck adaptor proteins.Nck proteins maintain the adult glomerular filtration barrier.Genomic characterization of Wilms' tumor suppressor 1 targets in nephron progenitor cells during kidney development.Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodinAnion exchanger 1 interacts with nephrin in podocytes.Progress in pathogenesis of proteinuria.Kin of IRRE-like Protein 2 Is a Phosphorylated Glycoprotein That Regulates Basal Insulin Secretion.Glomerular Filtration Barrier Assembly: An insightIdentification and characterization of novel Kirrel isoform during myogenesis.Endocytic Trafficking at the Mature Podocyte Slit Diaphragm.Slit diaphragm protein Neph1 and its signaling: a novel therapeutic target for protection of podocytes against glomerular injuryTyrosine kinase signaling in kidney glomerular podocytes.Signaling from the podocyte intercellular junction to the actin cytoskeleton.Claudins reign: The claudin/EMP/PMP22/γ channel protein family in C. elegansProteomic analysis of the kidney filtration barrier--Problems and perspectives.An update: the role of Nephrin inside and outside the kidney.Cell biology of mesangial cells: the third cell that maintains the glomerular capillary.The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review).Downregulation of the antioxidant protein peroxiredoxin 2 contributes to angiotensin II-mediated podocyte apoptosis.GLCCI1 is a novel component associated with the PI3K signaling pathway in podocyte foot processesPhosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1.Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC-γ1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis.aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface.Targeting Neph1 and ZO-1 protein-protein interaction in podocytes prevents podocyte injury and preserves glomerular filtration function.SIRP-alpha-CD47 system functions as an intercellular signal in the renal glomerulus.Glomerular proteins related to slit diaphragm and matrix adhesion in the foot processes are highly tyrosine phosphorylated in the normal rat kidney.ZO-1 regulates Erk, Smad1/5/8, Smad2, and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells.Identification of novel therapeutic target genes and pathway in pancreatic cancer by integrative analysis.Glomerulosclerosis Induced by Deficiency of Membrane-Associated Guanylate Kinase Inverted 2 in Kidney Podocytes.Acute Kidney Injury and Progression of Diabetic Kidney Disease.A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.Candidate genes in gastric cancer identified by constructing a weighted gene co-expression network.Proteinuric Kidney Diseases: A Podocyte's Slit Diaphragm and Cytoskeleton Approach
P2860
Q24645152-FCBC9829-0FFB-4B0B-83C6-82227CE68EDAQ27332403-745DAFFD-BDC3-427F-B173-D14950A0D404Q28118316-2C61BE1F-A36E-4BE9-9B6C-A5620B696A1DQ28565762-79F8F7AF-7F9A-4820-801C-7F557E7A14C1Q30009968-86802D1C-8842-406C-B0C5-87086B3DA5A3Q30157251-C6C5E69C-6341-4780-8581-62BE41540CACQ33714250-A5ADA039-7FC2-4962-9A72-28F857C8F662Q34110292-D54E4915-1F2C-4164-9D1A-1096538E1688Q34455334-56E871D1-C0A0-4E91-9797-0C7E0193C3A5Q36011008-EF95B5F5-7170-44C1-84E3-795BB8E5ACC9Q36283499-D9EA77C3-A81B-4DBA-88FD-7B16F1B9246EQ37214152-DC532C68-1315-4766-B289-68C1FF48E6EDQ37328061-F6B3B9B3-F963-4EBA-9E7E-1CA05CE0784EQ37662983-58AA571F-6B9F-4438-9B02-22962E64DD7CQ37683351-67B44DCC-8A19-4B8B-BAC0-A8782713D346Q37903259-2D405FF4-E3C2-423D-B9F9-D0928FC766B9Q38041666-BC30F1D4-32C3-4765-83BF-4FA4124B558CQ38199107-3D242A0D-353F-4DD7-8A17-B437DF2CED08Q38439599-0C1745A7-F55D-45DA-8259-695CADAD5A7EQ38447905-60720B3D-850F-4013-8176-4CFBFC538625Q38748205-E94DDE4C-1230-422D-B18B-0772F06B59B6Q39401616-A5F93DE9-3ED9-48F0-BD64-16D896693193Q39495561-5388665A-5818-4C43-A0C1-EE38394CD7CAQ39770356-2ED33F62-E782-4EE0-A468-332FFEE969F8Q41824937-17AE6ABA-7872-4538-B372-050AF5DC0132Q42133639-38B4310C-AF74-4B60-B787-002532BAC0D9Q42205315-0BFF82CA-7E90-42E8-B253-A00ECA36D9B9Q42362352-E31D83BA-4B74-46DC-B741-3878EE1729FBQ43017126-C45EBBC9-0E78-4E0F-854C-EDFCAF8FD09EQ43196261-3185FB07-8ECE-4003-9601-02708E98AB61Q44062699-FAFE23F6-7B88-42D2-8A17-68CE9E7510A1Q45905331-ACEEA222-735F-4A1F-B9A1-DE8E18E45155Q50983421-D88F6DC2-4809-4807-9A54-627F6C35E968Q52724019-2CEB9D5F-BE8D-4405-ACC5-DEF45895FB68Q54978439-AEFFA6E8-9B7A-4D48-AA4F-80DE95CDD5A3Q55346557-8BDF5938-DC42-4F62-86E8-139168C082E5Q57652246-D539EE68-8CB0-462B-A20D-D3D31BDA7B32
P2860
Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Neph1, a component of the kidn ...... signaling by binding to Grb2.
@en
Neph1, a component of the kidn ...... signaling by binding to Grb2.
@nl
type
label
Neph1, a component of the kidn ...... signaling by binding to Grb2.
@en
Neph1, a component of the kidn ...... signaling by binding to Grb2.
@nl
prefLabel
Neph1, a component of the kidn ...... signaling by binding to Grb2.
@en
Neph1, a component of the kidn ...... signaling by binding to Grb2.
@nl
P2093
P2860
P356
P1476
Neph1, a component of the kidn ...... signaling by binding to Grb2.
@en
P2093
Hidetaka Kosako
Hidetake Kurihara
Seisuke Hattori
Takashi Igarashi
Takashi Sekine
Tohru Tezuka
Yutaka Harita
P2860
P304
P356
10.1074/JBC.M707247200
P407
P577
2008-02-07T00:00:00Z