BMS-754807, a small-molecule inhibitor of insulin-like growth factor-1 receptor/insulin receptor, enhances gemcitabine response in pancreatic cancer.
about
IGF-IR Targeted Therapy: Past, Present and FutureA high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agentSerum Insulin-Like Growth Factor Axis and the Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis.Comparative benefits of Nab-paclitaxel over gemcitabine or polysorbate-based docetaxel in experimental pancreatic cancerBRCA-Monet: a breast cancer specific drug treatment mode-of-action network for treatment effective prediction using large scale microarray database.The dual PI3K/mTOR inhibitor NVP-BEZ235 enhances nab-paclitaxel antitumor response in experimental gastric cancer.Can we unlock the potential of IGF-1R inhibition in cancer therapy?Effects of insulin on human pancreatic cancer progression modeled in vitroSuperior antitumor activity of nanoparticle albumin-bound paclitaxel in experimental gastric cancer.Quantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R/IR signaling pathways in neuroblastoma.Enhancement of nab-paclitaxel antitumor activity through addition of multitargeting antiangiogenic agents in experimental pancreatic cancer.The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link.Nintedanib, a triple angiokinase inhibitor, enhances cytotoxic therapy response in pancreatic cancer.Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferationSilencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death.Augmentation of response to nab-paclitaxel by inhibition of insulin-like growth factor (IGF) signaling in preclinical pancreatic cancer models.Molecularly targeted co-delivery of a histone deacetylase inhibitor and paclitaxel by lipid-protein hybrid nanoparticles for synergistic combinational chemotherapy.Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination StudiesInhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: involvement of protein kinase C-θ activation.Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition.Trichosanthin enhances the antitumor effect of gemcitabine in non-small cell lung cancer via inhibition of the PI3K/AKT pathway.Insulin Receptor Isoforms in Physiology and Disease: An Updated View.
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BMS-754807, a small-molecule inhibitor of insulin-like growth factor-1 receptor/insulin receptor, enhances gemcitabine response in pancreatic cancer.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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name
BMS-754807, a small-molecule i ...... response in pancreatic cancer.
@en
BMS-754807, a small-molecule i ...... response in pancreatic cancer.
@nl
type
label
BMS-754807, a small-molecule i ...... response in pancreatic cancer.
@en
BMS-754807, a small-molecule i ...... response in pancreatic cancer.
@nl
prefLabel
BMS-754807, a small-molecule i ...... response in pancreatic cancer.
@en
BMS-754807, a small-molecule i ...... response in pancreatic cancer.
@nl
P2093
P1476
BMS-754807, a small-molecule i ...... response in pancreatic cancer.
@en
P2093
Changhua Zhang
Margaret A Schwarz
Niranjan Awasthi
Roderich E Schwarz
Winston Ruan
P304
P356
10.1158/1535-7163.MCT-12-0447
P577
2012-10-09T00:00:00Z