Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells
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Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical AppraisalAldehyde dehydrogenase as a marker and functional mediator of metastasis in solid tumorsEmerging role of cancer stem cells in the biology and treatment of ovarian cancer: basic knowledge and therapeutic possibilities for an innovative approachA conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma CareChemotherapy targeting cancer stem cellsDisulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosisNanoscale Reaction Vessels Designed for Synthesis of Copper-Drug Complexes Suitable for Preclinical DevelopmentDocosahexaenoic acid and disulfiram act in concert to kill cancer cells: a mutual enhancement of their anticancer actionsA functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system.ABC transporters in CSCs membranes as a novel target for treating tumor relapse.Aggravated DNA damage as a basis for enhanced glioma cell killing by MJ-66 in combination with minocycline.Liposome encapsulated Disulfiram inhibits NFκB pathway and targets breast cancer stem cells in vitro and in vivo.CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide.Disulfiram-induced cytotoxicity and endo-lysosomal sequestration of zinc in breast cancer cells.Concise review: bullseye: targeting cancer stem cells to improve the treatment of gliomas by repurposing disulfiram.The oxidative stress response of the filamentous yeast Trichosporon cutaneum R57 to copper, cadmium and chromium exposure.Disulfiram modulates stemness and metabolism of brain tumor initiating cells in atypical teratoid/rhabdoid tumors.A STAT3-NFkB/DDIT3/CEBPβ axis modulates ALDH1A3 expression in chemoresistant cell subpopulations.Notch signaling drives stemness and tumorigenicity of esophageal adenocarcinomaAccumulation of ALDH1-positive cells after neoadjuvant chemotherapy predicts treatment resistance and prognosticates poor outcome in ovarian cancer.Effects of PI3K inhibitor NVP-BKM120 on overcoming drug resistance and eliminating cancer stem cells in human breast cancer cellsCopper-boosting compounds: a novel concept for antimycobacterial drug discovery.Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway.Matrix metalloproteinase-1 induction by diethyldithiocarbamate is regulated via Akt and ERK/miR222/ETS-1 pathways in hepatic stellate cells.Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells.The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells.A2780 human ovarian cancer cells with acquired paclitaxel resistance display cancer stem cell properties.Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners.Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage.Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells.Effective elimination of adult B-lineage acute lymphoblastic leukemia by disulfiram/copper complex in vitro and in vivo in patient-derived xenograft models.Poly lactic-co-glycolic acid controlled delivery of disulfiram to target liver cancer stem-like cells.New molecules and old drugs as emerging approaches to selectively target human glioblastoma cancer stem cells.Investigating molecular profiles of ovarian cancer: an update on cancer stem cells.Copper as a key regulator of cell signalling pathways.The therapeutic potential of vaginal drug delivery in the treatment of cervical cancer.Cancer stem cells in hepatocellular carcinoma: Therapeutic implications based on stem cell biology.Aldehyde dehydrogenase activity plays no functional role in stem cell-like properties in anaplastic thyroid cancer cell lines.Disulfiram-loaded immediate and extended release vaginal tablets for the localised treatment of cervical cancer.Multidrug-resistant cancer cells and cancer stem cells hijack cellular systems to circumvent systemic therapies, can natural products reverse this?
P2860
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P2860
Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Cytotoxic effect of disulfiram ...... ositive cancer-stem-like cells
@en
Cytotoxic effect of disulfiram ...... sitive cancer-stem-like cells.
@nl
type
label
Cytotoxic effect of disulfiram ...... ositive cancer-stem-like cells
@en
Cytotoxic effect of disulfiram ...... sitive cancer-stem-like cells.
@nl
prefLabel
Cytotoxic effect of disulfiram ...... ositive cancer-stem-like cells
@en
Cytotoxic effect of disulfiram ...... sitive cancer-stem-like cells.
@nl
P2093
P2860
P356
P1476
Cytotoxic effect of disulfiram ...... ositive cancer-stem-like cells
@en
P2093
A L Armesilla
J L Darling
J-P Hugnot
P Channathodiyil
V Kannappan
P2860
P2888
P304
P356
10.1038/BJC.2012.442
P407
P577
2012-10-02T00:00:00Z