Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in.
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Structure and function of the telomeric CST complexStructure of the Human Telomeric Stn1-Ten1 Capping ComplexThe THO complex component Thp2 counteracts telomeric R-loops and telomere shorteningMammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrityThe telomere capping complex CST has an unusual stoichiometry, makes multipartite interaction with G-Tails, and unfolds higher-order G-tail structuresMERISTEM DISORGANIZATION1 encodes TEN1, an essential telomere protein that modulates telomerase processivity in Arabidopsis.Fission yeast Stn1 is crucial for semi-conservative replication at telomeres and subtelomeres.Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells.CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance.Human CST has independent functions during telomere duplex replication and C-strand fill-inThe role of double-strand break repair pathways at functional and dysfunctional telomeres.Role of STN1 and DNA polymerase α in telomere stability and genome-wide replication in Arabidopsis.The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch.Identification of Genes That Modulate Susceptibility to Formaldehyde and Imatinib by Functional Genomic Screening in Human Haploid KBM7 Cells.STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function.Human CST abundance determines recovery from diverse forms of DNA damage and replication stress.Suppression of STN1 enhances the cytotoxicity of chemotherapeutic agents in cancer cells by elevating DNA damage.Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.Human TEN1 maintains telomere integrity and functions in genome-wide replication restartCST for the grand finale of telomere replication.Molecular basis of telomere syndrome caused by CTC1 mutations.Cdk1 regulates the temporal recruitment of telomerase and Cdc13-Stn1-Ten1 complex for telomere replication.Cdc13 at a crossroads of telomerase actionIf the cap fits, wear it: an overview of telomeric structures over evolution.Telomere-end processing: mechanisms and regulation.Beyond Telomerase: Telomere Instability as a Novel Target for Cancer Therapy.Telomeres in cancer: tumour suppression and genome instability.DNA Replication Origins and Fork Progression at Mammalian TelomeresUbiquitination and SUMOylation in Telomere Maintenance and Dysfunction.The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells.DNA-Directed Polymerase Subunits Play a Vital Role in Human Telomeric Overhang Processing.Functional characterization of human CTC1 mutations reveals novel mechanisms responsible for the pathogenesis of the telomere disease Coats plus.Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication Stress.Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes.Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST.STN1-POLA2 interaction provides a basis for primase-pol α stimulation by human STN1.Looping-out mechanism for resolution of replicative stress at telomeres.Dynamic interactions of Arabidopsis TEN1: stabilizing telomeres in response to heat stress.Pathogenic CTC1 mutations cause global genome instabilities under replication stress.The MLH1 ATPase domain is needed for suppressing aberrant formation of interstitial telomeric sequences.
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Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Human Stn1 protects telomere i ...... nd mediating C-strand fill-in.
@en
Human Stn1 protects telomere i ...... nd mediating C-strand fill-in.
@nl
type
label
Human Stn1 protects telomere i ...... nd mediating C-strand fill-in.
@en
Human Stn1 protects telomere i ...... nd mediating C-strand fill-in.
@nl
prefLabel
Human Stn1 protects telomere i ...... nd mediating C-strand fill-in.
@en
Human Stn1 protects telomere i ...... nd mediating C-strand fill-in.
@nl
P2093
P2860
P356
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P1476
Human Stn1 protects telomere i ...... nd mediating C-strand fill-in.
@en
P2093
Chenhui Huang
Weihang Chai
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P2888
P304
P356
10.1038/CR.2012.132
P577
2012-09-11T00:00:00Z