MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR.
about
Recent advances in T-cell engineering for use in immunotherapyTCR affinity for p/MHC formed by tumor antigens that are self-proteins: impact on efficacy and toxicityA novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor controlT cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cellsT Cell Receptor Engineering and Analysis Using the Yeast Display Platform.New Strategies in Engineering T-cell Receptor Gene-Modified T cells to More Effectively Target MalignanciesCD4(+) and CD8(+) TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells.Enhanced-affinity murine T-cell receptors for tumor/self-antigens can be safe in gene therapy despite surpassing the threshold for thymic selection.Role of T cell receptor affinity in the efficacy and specificity of adoptive T cell therapies.Human leucocyte antigen class I-redirected anti-tumour CD4+ T cells require a higher T cell receptor binding affinity for optimal activity than CD8+ T cells.Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice.
P2860
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P2860
MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
MHC-class I-restricted CD4 T c ...... the micromolar wild-type TCR.
@en
MHC-class I-restricted CD4 T c ...... the micromolar wild-type TCR.
@nl
type
label
MHC-class I-restricted CD4 T c ...... the micromolar wild-type TCR.
@en
MHC-class I-restricted CD4 T c ...... the micromolar wild-type TCR.
@nl
prefLabel
MHC-class I-restricted CD4 T c ...... the micromolar wild-type TCR.
@en
MHC-class I-restricted CD4 T c ...... the micromolar wild-type TCR.
@nl
P2093
P2860
P1476
MHC-class I-restricted CD4 T c ...... the micromolar wild-type TCR.
@en
P2093
Adam S Chervin
Boris Engels
Carolina M Soto
David M Kranz
Edward J Roy
Hans Schreiber
Jennifer D Stone
P2860
P2888
P304
P356
10.1007/S00262-012-1336-Z
P577
2012-08-25T00:00:00Z