Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer. - Wikidata - wikimedia - TriplyDB

Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.

Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.

http://www.wikidata.org/entity/Q39302902

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Role of the vector genome and underlying factor IX mutation in immune responses to AAV gene therapy for hemophilia B Gene therapy for hemophilia Long-term amelioration of feline Mucopolysaccharidosis VI after AAV-mediated liver gene transfer Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity Evaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine models Immunomodulatory gene therapy prevents antibody formation and lethal hypersensitivity reactions in murine pompe disease.AAV's anatomy: roadmap for optimizing vectors for translational success GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects.AAV vectors avoid inflammatory signals necessary to render transduced hepatocyte targets for destructive T cells AAV-mediated liver-directed gene therapy.Transient B cell depletion or improved transgene expression by codon optimization promote tolerance to factor VIII in gene therapy.Hydrostatic isolated limb perfusion with adeno-associated virus vectors enhances correction of skeletal muscle in Pompe disease.High-efficiency transduction and correction of murine hemophilia B using AAV2 vectors devoid of multiple surface-exposed tyrosines.Development of Gene Transfer for Induction of Antigen-specific Tolerance.Portal vein delivery of viral vectors for gene therapy for hemophilia.Pompe disease gene therapy.The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver.Muscle-directed gene therapy for hemophilia B with more efficient and less immunogenic AAV vectors.Adeno-associated virus-mediated gene transfer leads to persistent hepatitis B virus replication in mice expressing HLA-A2 and HLA-DR1 molecules.Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid.Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies.Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery.AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells.The complex and evolving story of T cell activation to AAV vector-encoded transgene products.Immune tolerance induction in haemophilia: evidence and the way forward.Innate Immune Responses to AAV Vectors Development of Novel Recombinant AAV Vectors and Strategies for the Potential Gene Therapy of Hemophilia.In vivo induction of regulatory T cells for immune tolerance in hemophilia.Potential for cellular stress response to hepatic factor VIII expression from AAV vector Complexity of immune responses to AAV transgene products - Example of factor IX.Impact of the underlying mutation and the route of vector administration on immune responses to factor IX in gene therapy for hemophilia B.Liver-Directed Adeno-Associated Viral Gene Therapy for Hemophilia.Neonatal Gene Therapy for Hemophilia B by a Novel Adenovirus Vector Showing Reduced Leaky Expression of Viral Genes.The Balance between CD8+ T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose.Dynamics of antigen presentation to transgene product-specific CD4+ T cells and of Treg induction upon hepatic AAV gene transfer.In Vivo Gene Delivery to Lymph Node Stromal Cells Leads to Transgene-specific CD8+ T Cell Anergy in Mice.Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX.Pulmonary vasculature directed adenovirus increases epithelial lining fluid alpha-1 antitrypsin levels.Gene Therapy-Induced Antigen-Specific Tregs Inhibit Neuro-inflammation and Reverse Disease in a Mouse Model of Multiple Sclerosis.

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Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.

http://www.wikidata.org/entity/Q39302902

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

@zh

2009年學術文章

@zh-hant

name

Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.

@en

Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.

@nl

type

label

Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.

@en

Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.

@nl

prefLabel

Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.

@en

Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.

@nl

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Human Gene Therapy

P1476

Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.

@en

P2093

Brad E Hoffman

http://www.w3.org/2001/XMLSchema#string

Cox Terhorst

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Mario Cooper

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Ou Cao

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Roland W Herzog

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Sushrusha Nayak

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P2860

Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

Transduction efficiency and immune response associated with the administration of AAV8 vector into dog skeletal muscle.

Improved hepatic gene transfer by using an adeno-associated virus serotype 5 vector

Immune responses to adeno-associated virus vectors.

Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells.

Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer.

Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates

Immune implications of gene therapy for hemophilia.

Combination brain and systemic injections of AAV provide maximal functional and survival benefits in the Niemann-Pick mouse.

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767-776

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scholarly article

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10.1089/HUM.2008.161

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7

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20

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19309290

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2829279

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