Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.
about
Role of the vector genome and underlying factor IX mutation in immune responses to AAV gene therapy for hemophilia BGene therapy for hemophiliaLong-term amelioration of feline Mucopolysaccharidosis VI after AAV-mediated liver gene transferTolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicityEvaluation of engineered AAV capsids for hepatic factor IX gene transfer in murine and canine modelsImmunomodulatory gene therapy prevents antibody formation and lethal hypersensitivity reactions in murine pompe disease.AAV's anatomy: roadmap for optimizing vectors for translational successGITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cellsGene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects.AAV vectors avoid inflammatory signals necessary to render transduced hepatocyte targets for destructive T cellsAAV-mediated liver-directed gene therapy.Transient B cell depletion or improved transgene expression by codon optimization promote tolerance to factor VIII in gene therapy.Hydrostatic isolated limb perfusion with adeno-associated virus vectors enhances correction of skeletal muscle in Pompe disease.High-efficiency transduction and correction of murine hemophilia B using AAV2 vectors devoid of multiple surface-exposed tyrosines.Development of Gene Transfer for Induction of Antigen-specific Tolerance.Portal vein delivery of viral vectors for gene therapy for hemophilia.Pompe disease gene therapy.The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver.Muscle-directed gene therapy for hemophilia B with more efficient and less immunogenic AAV vectors.Adeno-associated virus-mediated gene transfer leads to persistent hepatitis B virus replication in mice expressing HLA-A2 and HLA-DR1 molecules.Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid.Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies.Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery.AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells.The complex and evolving story of T cell activation to AAV vector-encoded transgene products.Immune tolerance induction in haemophilia: evidence and the way forward.Innate Immune Responses to AAV VectorsDevelopment of Novel Recombinant AAV Vectors and Strategies for the Potential Gene Therapy of Hemophilia.In vivo induction of regulatory T cells for immune tolerance in hemophilia.Potential for cellular stress response to hepatic factor VIII expression from AAV vectorComplexity of immune responses to AAV transgene products - Example of factor IX.Impact of the underlying mutation and the route of vector administration on immune responses to factor IX in gene therapy for hemophilia B.Liver-Directed Adeno-Associated Viral Gene Therapy for Hemophilia.Neonatal Gene Therapy for Hemophilia B by a Novel Adenovirus Vector Showing Reduced Leaky Expression of Viral Genes.The Balance between CD8+ T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose.Dynamics of antigen presentation to transgene product-specific CD4+ T cells and of Treg induction upon hepatic AAV gene transfer.In Vivo Gene Delivery to Lymph Node Stromal Cells Leads to Transgene-specific CD8+ T Cell Anergy in Mice.Gene therapy for hemophilia B mice with scAAV8-LP1-hFIX.Pulmonary vasculature directed adenovirus increases epithelial lining fluid alpha-1 antitrypsin levels.Gene Therapy-Induced Antigen-Specific Tregs Inhibit Neuro-inflammation and Reverse Disease in a Mouse Model of Multiple Sclerosis.
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Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.
@en
Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.
@nl
type
label
Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.
@en
Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.
@nl
prefLabel
Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.
@en
Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.
@nl
P2093
P2860
P356
P1433
P1476
Improved induction of immune tolerance to factor IX by hepatic AAV-8 gene transfer.
@en
P2093
Brad E Hoffman
Cox Terhorst
Mario Cooper
Roland W Herzog
Sushrusha Nayak
P2860
P304
P356
10.1089/HUM.2008.161
P577
2009-07-01T00:00:00Z