The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver. - Wikidata - wikimedia - TriplyDB

The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver.

The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver.

http://www.wikidata.org/entity/Q35067592

about

Role of the vector genome and underlying factor IX mutation in immune responses to AAV gene therapy for hemophilia B Self-complementary AAVs induce more potent transgene product-specific immune responses compared to a single-stranded genome The interplay of post-translational modification and gene therapy Developments in the treatment of hemophilia B: focus on emerging gene therapy Gene therapy for hemophilia Liver-targeted gene therapy: Approaches and challenges Engineering antibody-like inhibitors to prevent and treat HIV-1 infection.Immune tolerance induction to factor IX through B cell gene transfer: TLR9 signaling delineates between tolerogenic and immunogenic B cells.Influence of immune responses in gene/stem cell therapies for muscular dystrophies.Cell-Mediated Immunity to AAV Vectors, Evolving Concepts and Potential Solutions.Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them.Activation of the cellular unfolded protein response by recombinant adeno-associated virus vectors.Intraganglionic AAV6 results in efficient and long-term gene transfer to peripheral sensory nervous system in adult rats.Development of Gene Transfer for Induction of Antigen-specific Tolerance.Perinatal gene transfer to the liver.Self-complementary adeno-associated viral vectors for gene therapy of hemophilia B: progress and challenges Unique Roles of TLR9- and MyD88-Dependent and -Independent Pathways in Adaptive Immune Responses to AAV-Mediated Gene Transfer Adeno-associated virus activates an innate immune response in normal human cells but not in osteosarcoma cells.Pharmacological modulation of humoral immunity in a nonhuman primate model of AAV gene transfer for hemophilia B.MyD88 signaling in B cells regulates the production of Th1-dependent antibodies to AAV The threefold protrusions of adeno-associated virus type 8 are involved in cell surface targeting as well as postattachment processing.An acidic oligopeptide displayed on AAV2 improves axial muscle tropism after systemic delivery.Gene Therapy for Duchenne muscular dystrophy.Deficiency in MyD88 Signaling Results in Decreased Antibody Responses to an Adeno-Associated Virus Vector in Murine Pompe Disease.Preclinical evaluation of an anti-HCV miRNA cluster for treatment of HCV infection Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells.Differential type I interferon-dependent transgene silencing of helper-dependent adenoviral vs. adeno-associated viral vectors in vivo.RNA Interference Mediated Interleukin-1β Silencing in Inflamed Chondrocytes Decreases Target and Downstream Catabolic Responses.Serotype-specific Binding Properties and Nanoparticle Characteristics Contribute to the Immunogenicity of rAAV1 Vectors Advanced Characterization of DNA Molecules in rAAV Vector Preparations by Single-stranded Virus Next-generation Sequencing.CpG-depleted adeno-associated virus vectors evade immune detection.IL12-mediated liver inflammation reduces the formation of AAV transcriptionally active forms but has no effect over preexisting AAV transgene expression.Immune responses to AAV vectors: overcoming barriers to successful gene therapy Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid.Targeted modifications in adeno-associated virus serotype 8 capsid improves its hepatic gene transfer efficiency in vivo A review of therapeutic prospects of non-viral gene therapy in the retinal pigment epithelium Gene Therapy for the Treatment of Neurological Disorders: Metabolic Disorders.Recombinant adeno-associated virus vectors in the treatment of rare diseases.AAV Vectors Vaccines Against Infectious Diseases.Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies

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The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver.

http://www.wikidata.org/entity/Q35067592

description

2011 nî lūn-bûn

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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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The genome of self-complementa ...... immune responses in the liver.

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The genome of self-complementa ...... immune responses in the liver.

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The genome of self-complementa ...... immune responses in the liver.

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The genome of self-complementa ...... immune responses in the liver.

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Ashley T Martino

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Babak Moghimi

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Brendan Lee

http://www.w3.org/2001/XMLSchema#string

Daniel A Muruve

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David M Markusic

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Hildegund C J Ertl

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Irene Zolotukhin

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Masataka Suzuki

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Renee C Ryals

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Roland W Herzog

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P2860

A Toll-like receptor recognizes bacterial DNA

Differential activation of innate immune responses by adenovirus and adeno-associated virus vectors

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

Identification of mouse AAV capsid-specific CD8+ T cell epitopes.

Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity

Hepatic gene transfer as a means of tolerance induction to transgene products

MyD88-dependent silencing of transgene expression during the innate and adaptive immune response to helper-dependent adenovirus.

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition.

AAV vectors avoid inflammatory signals necessary to render transduced hepatocyte targets for destructive T cells

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6459-6468

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10.1182/BLOOD-2010-10-314518

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24

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Toll-like receptor

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3123017

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