Global structural changes in hepatitis B virus capsids induced by the assembly effector HAP1.
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Current Landscape of Antiviral Drug DiscoveryGeometric considerations in virus capsid size specificity, auxiliary requirements, and bucklingConformational Changes in the Hepatitis B Virus Core Protein Are Consistent with a Role for Allostery in Virus AssemblyEpitope insertion at the N-terminal molecular switch of the rabbit hemorrhagic disease virus T = 3 capsid protein leads to larger T = 4 capsids.Thermodynamic origins of protein folding, allostery, and capsid formation in the human hepatitis B virus core proteinAssembly-Directed Antivirals Differentially Bind Quasiequivalent Pockets to Modify Hepatitis B Virus Capsid Tertiary and Quaternary StructureNuclear entry of hepatitis B virus capsids involves disintegration to protein dimers followed by nuclear reassociation to capsidsProtruding Features of Viral Capsids Are Clustered on Icosahedral Great CirclesAll-Atom Molecular Dynamics of Virus Capsids as Drug TargetsA structural model for duck hepatitis B virus core protein derived by extensive mutagenesis.The thermodynamics of virus capsid assembly.Allosteric conformational changes of human HBV core protein transform its assembly.Full-length hepatitis B virus core protein packages viral and heterologous RNA with similarly high levels of cooperativityA kinase chaperones hepatitis B virus capsid assembly and captures capsid dynamics in vitro.Trapping of hepatitis B virus capsid assembly intermediates by phenylpropenamide assembly accelerators.Evolution and protein packaging of small-molecule RNA aptamers.A novel pyridazinone derivative inhibits hepatitis B virus replication by inducing genome-free capsid formationIn vitro screening for molecules that affect virus capsid assembly (and other protein association reactions)Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation.High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core proteinConformational equilibria and rates of localized motion within hepatitis B virus capsidsPhase diagrams map the properties of antiviral agents directed against hepatitis B virus core assemblyHepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine PocketUnnatural amino acid incorporation into virus-like particlesElucidating the mechanism behind irreversible deformation of viral capsids.Virus assembly, allostery and antiviralsRecent advance of the hepatitis B virus inhibitors: a medicinal chemistry overview.Core as a novel viral target for hepatitis C drugs.Core protein: A pleiotropic keystone in the HBV lifecycle.Assembly and Release of Hepatitis B Virus.Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors.Detection of late intermediates in virus capsid assembly by charge detection mass spectrometry.The current status and future directions of hepatitis B antiviral drug discovery.Nanoparticle-induced morphological transition of Bombyx mori nucleopolyhedrovirus: a novel method to treat silkworm grasserie disease.Genetically altering the thermodynamics and kinetics of hepatitis B virus capsid assembly has profound effects on virus replication in cell culture.A Molecular Breadboard: Removal and Replacement of Subunits in an Hepatitis B Virus Capsid.Discovery and Mechanistic Study of Benzamide Derivatives That Modulate Hepatitis B Virus Capsid Assembly.Yield Optimisation of Hepatitis B Virus Core Particles in E. coli Expression System for Drug Delivery Applications.Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular MechanismsProtein-Protein Interfaces in Viral Capsids Are Structurally Unique.
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P2860
Global structural changes in hepatitis B virus capsids induced by the assembly effector HAP1.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
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2006年學術文章
@zh-hant
name
Global structural changes in h ...... by the assembly effector HAP1.
@en
Global structural changes in h ...... by the assembly effector HAP1.
@nl
type
label
Global structural changes in h ...... by the assembly effector HAP1.
@en
Global structural changes in h ...... by the assembly effector HAP1.
@nl
prefLabel
Global structural changes in h ...... by the assembly effector HAP1.
@en
Global structural changes in h ...... by the assembly effector HAP1.
@nl
P2860
P356
P1433
P1476
Global structural changes in h ...... by the assembly effector HAP1.
@en
P2093
Christina R Bourne
P2860
P304
11055-11061
P356
10.1128/JVI.00933-06
P407
P577
2006-08-30T00:00:00Z