Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells.
about
6-thioguanine: a drug with unrealized potential for cancer therapy.Collateral Lethality: A new therapeutic strategy in oncologyExpression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function.Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine.Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance.Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination.Characterization of MTAP Gene Expression in Breast Cancer Patients and Cell LinesQuantitation of cellular metabolic fluxes of methionine.
P2860
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P2860
Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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name
Increasing the therapeutic ind ...... g loss of MTAP in tumor cells.
@en
Increasing the therapeutic ind ...... g loss of MTAP in tumor cells.
@nl
type
label
Increasing the therapeutic ind ...... g loss of MTAP in tumor cells.
@en
Increasing the therapeutic ind ...... g loss of MTAP in tumor cells.
@nl
prefLabel
Increasing the therapeutic ind ...... g loss of MTAP in tumor cells.
@en
Increasing the therapeutic ind ...... g loss of MTAP in tumor cells.
@nl
P2093
P2860
P356
P1476
Increasing the therapeutic ind ...... g loss of MTAP in tumor cells.
@en
P2093
Baiqing Tang
Joseph R Testa
Warren D Kruger
P2860
P304
P356
10.4161/CBT.21115
P577
2012-07-24T00:00:00Z