A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.
about
Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.)New Therapeutic Concept of NAD Redox Balance for Cisplatin NephrotoxicityChemical cross-linking and native mass spectrometry: A fruitful combination for structural biologyCisplatin-induced Kidney Dysfunction and Perspectives on Improving Treatment StrategiesAugmentation of NAD(+) by NQO1 attenuates cisplatin-mediated hearing impairment.Use of NQO1 status as a selective biomarker for oesophageal squamous cell carcinomas with greater sensitivity to 17-AAGPathophysiology of cisplatin-induced acute kidney injury.Regulating the 20S proteasome ubiquitin-independent degradation pathway.Paradigms of protein degradation by the proteasome.RNA profiles of porcine embryos during genome activation reveal complex metabolic switch sensitive to in vitro conditions.Regulation of Proteasomal Degradation by Modulating Proteasomal Initiation RegionsRecognition of enzymes lacking bound cofactor by protein quality control.Pharmacological activation of NQO1 increases NAD⁺ levels and attenuates cisplatin-mediated acute kidney injury in mice.Exposing the subunit diversity and modularity of protein complexes by structural mass spectrometry approaches.Tuning the proteasome to brighten the end of the journey.The Parkinson's-associated protein DJ-1 regulates the 20S proteasome.Mass Spectrometry: A Technique of Many Faces.The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1.AAA-ATPases in Protein Degradation.HIV-1 Rev downregulates Tat expression and viral replication via modulation of NAD(P)H:quinine oxidoreductase 1 (NQO1).Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch.Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.Isg15 controls p53 stability and functions.Molecular recognition of PTS-1 cargo proteins by Pex5p: implications for protein mistargeting in primary hyperoxaluria.Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.Native Mass Spectrometry of Recombinant Proteins from Crude Cell Lysates.Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer.Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution.Post-translational regulation of p53 function through 20S proteasome-mediated cleavage.A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R.Evolutionary Divergent Suppressor Mutations in Conformational Diseases
P2860
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P2860
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.
@en
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.
@nl
type
label
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.
@en
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.
@nl
prefLabel
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.
@en
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.
@nl
P2093
P50
P1433
P1476
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.
@en
P2093
Gili Ben-Nissan
Hodaya Keisar
Nimrod Hazan
Oren Moscovitz
Yosef Shaul
P356
10.1016/J.MOLCEL.2012.05.049
P577
2012-07-01T00:00:00Z