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A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.Ubiquitin-independent p53 proteasomal degradation.Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers.The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1.A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.NADH binds and stabilizes the 26S proteasomes independent of ATP.BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein.Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response.The nanny model for IDPs.Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.Oncogenic addiction to high 26S proteasome level.Thermo-resistant intrinsically disordered proteins are efficient 20S proteasome substratesDetermination of IUP based on susceptibility for degradation by defaultIn-cell identification and measurement of RNA-protein interactionsMitochondrial metabolism promotes adaptation to proteotoxic stressAuthor Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Peter Tsvetkov
@ast
Peter Tsvetkov
@en
Peter Tsvetkov
@es
Peter Tsvetkov
@nl
type
label
Peter Tsvetkov
@ast
Peter Tsvetkov
@en
Peter Tsvetkov
@es
Peter Tsvetkov
@nl
prefLabel
Peter Tsvetkov
@ast
Peter Tsvetkov
@en
Peter Tsvetkov
@es
Peter Tsvetkov
@nl
P106
P31
P496
0000-0002-7577-2342