Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway - Wikidata - wikimedia - TriplyDB

Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway

Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway

http://www.wikidata.org/entity/Q39316242

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Extension of chronological life span in yeast by decreased TOR pathway signaling Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis Lin28 enhances tissue repair by reprogramming cellular metabolism Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy.Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancer.Radiotherapy suppresses angiogenesis in mice through TGF-betaRI/ALK5-dependent inhibition of endothelial cell sprouting Icariside II induces cell cycle arrest and apoptosis in human glioblastoma cells through suppressing Akt activation and potentiating FOXO3a activity.Circadian clocks and vascular function Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway KNDC1 knockdown protects human umbilical vein endothelial cells from senescence.The "O" class: crafting clinical care with FoxO transcription factors.Pro-oncogenic and anti-oncogenic pathways: opportunities and challenges of cancer therapy.FoxO3a and disease progression.Senescence and apoptosis: dueling or complementary cell fates?Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol.The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors.Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescence Vascular homeostasis and angiogenesis determine therapeutic effectiveness in type 2 diabetes.PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis.Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence.A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis.Regulation of DMD pathology by an ankyrin-encoded miRNA.PPARδ coordinates angiotensin II-induced senescence in vascular smooth muscle cells through PTEN-mediated inhibition of superoxide generation.RhoA-mediated signaling in Notch-induced senescence-like growth arrest and endothelial barrier dysfunction.Perspectives of Targeting mTORC1-S6K1 in Cardiovascular Aging Angiotensin type I receptor blockade in conjunction with enhanced Akt activation restores coronary collateral growth in the metabolic syndrome.Signaling and Damaging Functions of Free Radicals in Aging-Free Radical Theory, Hormesis, and TOR.Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation.AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy.3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation.Why yeast cells can undergo apoptosis: death in times of peace, love, and war Impaired apoptosis and immune senescence - cause or effect?DNA damage, cellular senescence and organismal ageing: causal or correlative?Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence.An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations.PTEN, more than the AKT pathway."Sly as a FOXO": new paths with Forkhead signaling in the brain OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins

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P2860

Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway

http://www.wikidata.org/entity/Q39316242

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2004 nî lūn-bûn

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Akt negatively regulates the i ...... ia a p53/p21-dependent pathway

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The EMBO Journal

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Akt negatively regulates the i ...... ia a p53/p21-dependent pathway

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Haruhiro Toko

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Hideyuki Miyauchi

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Kaoru Tateno

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Takeshige Kunieda

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P2860

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

The phosphoinositide 3-kinase pathway

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

A C. elegans mutant that lives twice as long as wild type

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